Module 130 -- Complement

Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets: 5
Num genes: 23 (see 1969 additional genes for this module)
Num experiments: 352 (173 induced, 179 repressed)
Parent module: None
Children modules: 58


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
Complement Activation, Classical Pathway
complement activity
complement activation, classical pathway
regulation of complement activation
complement activation


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation Category P-value Hits Hits(%) Module hits in category Arrays in annotation Arrays
Liver tissue (Liver cancer*) Liver cancer* 5.8e-43 81 46.8 173 187 1945
Liver tissue, cancer or cell line (Liver cancer*) Liver cancer* 8.1e-41 81 46.8 173 197 1945
Cancer and cell line (Lung cancer*) Lung cancer* 1.5e-36 88 49.1 179 252 1945
Cancer (Lung cancer*) Lung cancer* 1.5e-36 88 49.1 179 252 1945
Lung tissue, cancer or cell line (Lung cancer*) Lung cancer* 6.7e-33 88 49.1 179 276 1945
Lung cancer (Lung cancer*) Lung cancer* 2.8e-30 79 44.1 179 238 1945
Lung cancer or cell line (Lung cancer*) Lung cancer* 2.8e-30 79 44.1 179 238 1945
Hepatitis infected liver (Liver cancer*) Liver cancer* 4.3e-27 60 34.6 173 156 1945
Non small cell lung cancer and cell line (Lung cancer*) Lung cancer* 1.1e-14 54 30.1 179 205 1945
Non small cell lung cancer (Lung cancer*) Lung cancer* 1.1e-14 54 30.1 179 205 1945
Non-tumor liver tissue (Liver cancer) Liver cancer 6.4e-12 53 65.4 81 76 207
Lung carcinoid (Lung cancer) Lung cancer 2.3e-11 20 22.7 88 20 276
Cancer and cell line (Liver cancer) Liver cancer 6.5e-11 41 100 41 126 207
Liver cancer cell line (Liver cancer) Liver cancer 3.5e-08 10 24.3 41 10 207
Cell line (Liver cancer) Liver cancer 3.3e-07 10 24.3 41 11 207
Cell line (Breast cancer) Breast cancer 7.1e-07 13 68.4 19 30 152
Metastasis (Liver cancer) Liver cancer 1.8e-06 9 21.9 41 10 207
Normal tissue (Liver cancer) Liver cancer 2.5e-05 13 16.0 81 14 207
Breast cancer cell line (Breast cancer) Breast cancer 0.0001 8 42.1 19 17 152
Squamous cell lung cancer (Lung cancer) Lung cancer 0.0002 21 23.8 88 35 276
Colon cancer (Liver cancer) Liver cancer 0.0002 5 12.1 41 5 207
Colon cancer metastasis to liver (Liver cancer) Liver cancer 0.0002 5 12.1 41 5 207
Colon cancer or cell line (Liver cancer) Liver cancer 0.0002 5 12.1 41 5 207
Colon tissue, cancer or cell line (Liver cancer) Liver cancer 0.0002 5 12.1 41 5 207


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation P-value Hits Hits(%) Module genes Genes in annotation Genes
complement activation 4.9e-53 21 100 21 26 4566
regulation of complement activation 1.8e-49 20 95.2 21 25 4566
complement activation\, classical pathway 8.6e-44 18 85.7 21 22 4566
humoral immune response 7.1e-35 21 100 21 118 4566
complement activity 1.8e-32 14 66.6 21 18 4566
response to pest/pathogen/parasite 1.0e-31 21 100 21 163 4566
immune response 1.1e-21 21 100 21 469 4566
response to biotic stimulus 2.2e-19 21 100 21 600 4566
defense/immunity protein activity 3.6e-19 14 66.6 21 103 4566
response to stress 8.4e-17 21 100 21 792 4566
complement activation\, alternative pathway 1.6e-15 7 33.3 21 10 4566
cytolysis 5.2e-09 5 23.8 21 16 4566
response to pathogenic bacteria 6.8e-08 4 19.0 21 10 4566
extracellular space 1.5e-07 9 42.8 21 212 4566
chymotrypsin activity 1.8e-06 5 23.8 21 48 4566
trypsin activity 2.2e-06 5 23.8 21 50 4566
serine-type endopeptidase activity 1.1e-05 5 23.8 21 69 4566
cell death 2.1e-05 6 28.5 21 134 4566
serine-type peptidase activity 2.3e-05 5 23.8 21 80 4566
endopeptidase activity 6.6e-05 5 23.8 21 99 4566


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Visual display
Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.
You can also view the images within GeneXPress by loading the module gxp file file.
 
 





 >4x