Module 159 -- Translation regulation

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General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets: 2
Num genes: 81 (see 2163 additional genes for this module)
Num experiments: 160 (58 induced, 102 repressed)
Parent module: None
Children modules: None


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Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
translation regulator activity
translation factor activity, nucleic acid binding


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Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation Category P-value Hits Hits(%) Module hits in category Arrays in annotation Arrays
Prostate (Prostate cancer*) Prostate cancer* 1.3e-24 37 36.6 101 101 1945
Hematologic cancer and cell line (Stimulated immune*) Stimulated immune* 8.6e-11 14 24.1 58 53 1945
Hematologic samples and cell lines (Stimulated immune*) Stimulated immune* 8.6e-11 14 24.1 58 53 1945
Macrophages (Stimulated immune*) Stimulated immune* 8.6e-11 14 24.1 58 53 1945
Monocytes (Stimulated immune*) Stimulated immune* 8.6e-11 14 24.1 58 53 1945
CNS cancer or cell line (Neuro tumors*) Neuro tumors* 1.4e-10 21 20.7 101 81 1945
CNS tumor (Neuro tumors*) Neuro tumors* 1.4e-10 21 20.7 101 81 1945
CNS tissue, cancer or cell line (Neuro tumors*) Neuro tumors* 3.9e-10 21 20.7 101 85 1945
Cancer and cell line (Neuro tumors*) Neuro tumors* 5.0e-10 21 20.7 101 86 1945
Cancer (Neuro tumors*) Neuro tumors* 5.0e-10 21 20.7 101 86 1945
Hematologic cancer and cell line (Stimulated immune*) Stimulated immune* 2.3e-08 15 14.8 101 53 1945
Hematologic samples and cell lines (Stimulated immune*) Stimulated immune* 2.3e-08 15 14.8 101 53 1945
Macrophages (Stimulated immune*) Stimulated immune* 2.3e-08 15 14.8 101 53 1945
Monocytes (Stimulated immune*) Stimulated immune* 2.3e-08 15 14.8 101 53 1945
Prostate (Prostate cancer*) Prostate cancer* 4.1e-06 13 22.4 58 101 1945
Atypical teratoid/rhabdoid tumour - CNS and other origin (Neuro tumors) Neuro tumors 3.2e-05 5 83.3 6 10 90


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Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation P-value Hits Hits(%) Module genes Genes in annotation Genes
translation regulator activity 1.2e-125 81 100 81 172 4566
translation factor activity\, nucleic acid binding 1.0e-113 74 91.3 81 139 4566
nucleic acid binding 8.0e-83 80 98.7 81 444 4566
translation release factor activity 3.2e-50 40 49.3 81 90 4566
GTP binding 6.7e-44 39 48.1 81 111 4566
translation initiation factor activity 5.4e-38 24 29.6 81 31 4566
GTPase activity 1.4e-31 29 35.8 81 85 4566
protein biosynthesis 2.1e-30 34 41.9 81 151 4566
small monomeric GTPase activity 4.1e-26 23 28.3 81 61 4566
translational initiation 4.6e-26 18 22.2 81 28 4566
regulation of translational initiation 3.8e-25 16 19.7 81 21 4566
hydrolase activity\, acting on acid anhydrides\, in phosphorus-containing anhydrides 4.6e-24 27 33.3 81 118 4566
small GTPase mediated signal transduction 2.1e-21 23 28.3 81 92 4566
translation elongation factor activity 3.5e-17 11 13.5 81 15 4566
eukaryotic 43S pre-initiation complex 1.1e-16 9 11.1 81 9 4566
RAB small monomeric GTPase activity 4.0e-15 11 13.5 81 20 4566
eukaryotic translation initiation factor 3 complex 4.2e-13 7 8.6 81 7 4566
translational elongation 2.3e-12 9 11.1 81 17 4566
intracellular signaling cascade 7.3e-11 25 30.8 81 319 4566
hydrolase activity 2.6e-08 35 43.2 81 783 4566
eukaryotic translation initiation factor 4 complex 3.1e-08 5 6.1 81 7 4566
protein transporter activity 4.8e-08 12 14.8 81 92 4566
regulation of protein biosynthesis 2.1e-05 3 3.7 81 4 4566
RAS small monomeric GTPase activity 2.7e-05 4 4.9 81 11 4566


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Visual display
Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.
You can also view the images within GeneXPress by loading the module gxp file file.
 
 





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