Module 181

Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets: 29
Num genes: 306 (see 642 additional genes for this module)
Num experiments: 479 (118 induced, 361 repressed)
Parent module: 242
Children modules: 104


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
Lessnick02 26
Bhattacharjee01 11
Bhattacharjee01 18
Lessnick02 15
Armstrong01 11
Nutt03 38
Bhattacharjee01 25
Armstrong01 48
Singh02 6
Singh02 12
Lessnick02 25
Singh02 5
Singh02 2
Singh02 3
Armstrong01 12
Nutt03 43
Singh02 20
Singh02 13
Nutt03 36
Singh02 42
Singh02 10
Nutt03 41
Armstrong01 4
Lessnick02 3
Singh02 23
Lessnick02 36
Bhattacharjee01 23
Armstrong01 21
Armstrong01 26


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation Category P-value Hits Hits(%) Module hits in category Arrays in annotation Arrays
Lung tissue, cancer or cell line (Lung cancer*) Lung cancer* 4.5e-39 138 38.2 361 276 1945
Non small cell lung cancer and cell line (Lung cancer*) Lung cancer* 1.0e-34 111 30.7 361 205 1945
Non small cell lung cancer (Lung cancer*) Lung cancer* 1.0e-34 111 30.7 361 205 1945
Prostate (Prostate cancer*) Prostate cancer* 4.2e-34 73 20.2 361 101 1945
Lung cancer (Lung cancer*) Lung cancer* 1.3e-30 116 32.1 361 238 1945
Lung cancer or cell line (Lung cancer*) Lung cancer* 1.3e-30 116 32.1 361 238 1945
Cancer and cell line (Lung cancer*) Lung cancer* 1.5e-30 120 33.2 361 252 1945
Cancer (Lung cancer*) Lung cancer* 1.5e-30 120 33.2 361 252 1945
Prostate (Prostate cancer*) Prostate cancer* 5.0e-12 27 22.8 118 101 1945
Lung carcinoid (Lung cancer) Lung cancer 1.5e-09 13 41.9 31 20 276
Cancer and cell line (Fibroblast EWS-FLI*) Fibroblast EWS-FLI* 4.3e-08 10 2.7 361 10 1945
Cell line (Fibroblast EWS-FLI*) Fibroblast EWS-FLI* 4.3e-08 10 2.7 361 10 1945
EWS/FLI expressing fibroblasts (Fibroblast EWS-FLI*) Fibroblast EWS-FLI* 4.3e-08 10 2.7 361 10 1945
Fibroblasts (Fibroblast EWS-FLI*) Fibroblast EWS-FLI* 4.3e-08 10 2.7 361 10 1945
Skin fibroblasts (Fibroblast EWS-FLI*) Fibroblast EWS-FLI* 4.3e-08 10 2.7 361 10 1945
B cells (Leukemia) Leukemia 2.0e-07 17 100 17 62 141
Bone marrow (Leukemia) Leukemia 1.3e-06 11 64.7 17 23 141
Cancer and cell line (Gliomas*) Gliomas* 1.6e-06 23 6.3 361 47 1945
Cancer (Gliomas*) Gliomas* 1.6e-06 23 6.3 361 47 1945
CNS cancer or cell line (Gliomas*) Gliomas* 1.6e-06 23 6.3 361 47 1945
CNS tissue, cancer or cell line (Gliomas*) Gliomas* 1.6e-06 23 6.3 361 47 1945
CNS tumor (Gliomas*) Gliomas* 1.6e-06 23 6.3 361 47 1945
Atypical teratoid/rhabdoid tumour - CNS and other origin (Neuro tumors) Neuro tumors 2.2e-05 7 53.8 13 10 90
Lung cancer (Lung cancer*) Lung cancer* 3.6e-05 30 25.4 118 238 1945
Lung cancer or cell line (Lung cancer*) Lung cancer* 3.6e-05 30 25.4 118 238 1945
Cancer and cell line (Lung cancer*) Lung cancer* 4.2e-05 31 26.2 118 252 1945
Cancer (Lung cancer*) Lung cancer* 4.2e-05 31 26.2 118 252 1945
Acute lymphocytic leukemia (Leukemia) Leukemia 0.0002 19 100 19 99 149
Lung tissue, cancer or cell line (Lung cancer*) Lung cancer* 0.0002 31 26.2 118 276 1945
Lymphocytes (Leukemia) Leukemia 0.0003 17 100 17 91 141


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation P-value Hits Hits(%) Module genes Genes in annotation Genes
fertilization 8.4e-05 3 1.4 201 3 4566


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Visual display
Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.
You can also view the images within GeneXPress by loading the module gxp file file.
Note: Since there are 479 experiments, this image does not display the individual experiment names, but rather condenses each experiment to a single pixel without displaying its name. You can fully view the image for this module within GeneXPress, by loading any of the four files mentioned in the line above
 
 





 >4x