Module 183 -- RNA splicing

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General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets: 6
Num genes: 65 (see 1679 additional genes for this module)
Num experiments: 165 (73 induced, 92 repressed)
Parent module: None
Children modules: None


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Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
pre_mRNA splicing factor activity
RNA processing
RNA metabolism
mRNA binding
mRNA splicing
RNA splicing


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Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation Category P-value Hits Hits(%) Module hits in category Arrays in annotation Arrays
Lymphoma (B lymphoma) B lymphoma 1.3e-07 13 100 13 77 245
Prostate (Prostate cancer*) Prostate cancer* 4.2e-07 18 19.5 92 101 1945
Hematologic cancer and cell line (Stimulated immune*) Stimulated immune* 3.2e-06 12 13.0 92 53 1945
Hematologic samples and cell lines (Stimulated immune*) Stimulated immune* 3.2e-06 12 13.0 92 53 1945
Macrophages (Stimulated immune*) Stimulated immune* 3.2e-06 12 13.0 92 53 1945
Monocytes (Stimulated immune*) Stimulated immune* 3.2e-06 12 13.0 92 53 1945
Hematologic samples and cell lines (B lymphoma) B lymphoma 7.3e-05 13 100 13 121 245
Hematologic cancer and cell line (Stimulated immune*) Stimulated immune* 0.0001 9 12.3 73 53 1945
Hematologic samples and cell lines (Stimulated immune*) Stimulated immune* 0.0001 9 12.3 73 53 1945
Macrophages (Stimulated immune*) Stimulated immune* 0.0001 9 12.3 73 53 1945
Monocytes (Stimulated immune*) Stimulated immune* 0.0001 9 12.3 73 53 1945
Hematologic samples and cell lines (Various tumors) Various tumors 0.0001 9 75 12 37 154
Hematologic samples (Various tumors) Various tumors 0.0001 9 75 12 37 154
Liver cancer cell line (Liver cancer) Liver cancer 0.0003 4 44.4 9 10 207


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation P-value Hits Hits(%) Module genes Genes in annotation Genes
RNA processing 6.7e-121 65 100 65 99 4566
RNA metabolism 7.1e-76 49 75.3 65 92 4566
RNA binding 4.7e-66 57 87.6 65 249 4566
RNA splicing 2.1e-64 40 61.5 65 63 4566
mRNA splicing 6.0e-56 34 52.3 65 49 4566
nucleic acid binding 2.1e-52 58 89.2 65 444 4566
nuclease activity 2.2e-46 45 69.2 65 215 4566
mRNA binding 7.2e-45 29 44.6 65 47 4566
pre-mRNA splicing factor activity 1.9e-40 25 38.4 65 36 4566
mRNA processing 2.1e-36 24 36.9 65 40 4566
transcription from Pol I promoter 1.3e-26 19 29.2 65 38 4566
hydrolase activity 3.3e-25 49 75.3 65 783 4566
spliceosome complex 2.8e-17 12 18.4 65 23 4566
heterogeneous nuclear ribonucleoprotein 4.6e-17 10 15.3 65 13 4566
nucleus 6.4e-17 45 69.2 65 966 4566
ribonucleoprotein complex 1.4e-15 26 40 65 283 4566
transcription\, DNA-dependent 2.9e-15 21 32.3 65 167 4566
transcription 2.1e-14 21 32.3 65 184 4566
endomembrane system 4.6e-14 43 66.1 65 1029 4566
single-stranded RNA binding 5.1e-13 8 12.3 65 12 4566
catalytic activity 8.2e-13 52 80 65 1677 4566
small nuclear ribonucleoprotein 1.3e-12 8 12.3 65 13 4566
spliceosome assembly 2.9e-12 7 10.7 65 9 4566
small nucleolar ribonucleoprotein complex 9.8e-12 7 10.7 65 10 4566
binding 5.2e-08 36 55.3 65 1103 4566
tRNA metabolism 4.9e-06 5 7.6 65 19 4566


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Visual display
Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.
You can also view the images within GeneXPress by loading the module gxp file file.
 
 





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