Module 2 -- DRG (dorsal root ganglia) genes

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General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets: 2
Num genes: 384 (see 3102 additional genes for this module)
Num experiments: 1318 (374 induced, 944 repressed)
Parent module: None
Children modules: None


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
DRG_2
DRG_1


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Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation Category P-value Hits Hits(%) Module hits in category Arrays in annotation Arrays
Liver tissue (Liver cancer*) Liver cancer* 7.4e-26 96 25.7 373 187 1945
Cancer and cell line (Lung cancer*) Lung cancer* 4.7e-25 197 20.8 943 252 1945
Cancer (Lung cancer*) Lung cancer* 4.7e-25 197 20.8 943 252 1945
Liver tissue, cancer or cell line (Liver cancer*) Liver cancer* 1.3e-23 96 25.7 373 197 1945
Lung cancer (Lung cancer*) Lung cancer* 2.9e-22 184 19.5 943 238 1945
Lung cancer or cell line (Lung cancer*) Lung cancer* 2.9e-22 184 19.5 943 238 1945
Hepatitis infected liver (Liver cancer*) Liver cancer* 1.7e-18 76 20.3 373 156 1945
CNS tissue, cancer or cell line (Neuro tumors*) Neuro tumors* 3.6e-18 78 8.2 943 85 1945
Non small cell lung cancer and cell line (Lung cancer*) Lung cancer* 3.7e-18 157 16.6 943 205 1945
Non small cell lung cancer (Lung cancer*) Lung cancer* 3.7e-18 157 16.6 943 205 1945
CNS cancer or cell line (Neuro tumors*) Neuro tumors* 4.4e-18 75 7.9 943 81 1945
CNS tumor (Neuro tumors*) Neuro tumors* 4.4e-18 75 7.9 943 81 1945
Lung tissue, cancer or cell line (Lung cancer*) Lung cancer* 8.2e-18 199 21.1 943 276 1945
Cancer and cell line (Neuro tumors*) Neuro tumors* 2.1e-17 78 8.2 943 86 1945
Cancer (Neuro tumors*) Neuro tumors* 2.1e-17 78 8.2 943 86 1945
Non-tumor liver tissue (Liver cancer) Liver cancer 4.5e-17 64 65.9 97 76 207
Cancer and cell line (Liver cancer) Liver cancer 2.0e-15 70 94.5 74 126 207
Cancer and cell line (Various tumors*) Various tumors* 3.8e-11 83 8.8 943 105 1945
Cancer (Various tumors*) Various tumors* 3.8e-11 83 8.8 943 105 1945
Acute leukemia (Leukemia*) Leukemia* 6.8e-10 103 10.9 943 141 1945
Cancer and cell line (Leukemia*) Leukemia* 6.8e-10 103 10.9 943 141 1945
Cancer (Leukemia*) Leukemia* 6.8e-10 103 10.9 943 141 1945
Hematologic cancer and cell line (Leukemia*) Leukemia* 6.8e-10 103 10.9 943 141 1945
Hematologic cancer (Leukemia*) Leukemia* 6.8e-10 103 10.9 943 141 1945
Hematologic samples and cell lines (Leukemia*) Leukemia* 6.8e-10 103 10.9 943 141 1945
Leukemia (Leukemia*) Leukemia* 6.8e-10 103 10.9 943 141 1945
Leukemia or leukemia cell line (Leukemia*) Leukemia* 6.8e-10 103 10.9 943 141 1945
Monocytes (Leukemia*) Leukemia* 6.8e-10 103 10.9 943 141 1945
Hematologic samples and cell lines (Various tumors) Various tumors 3.8e-09 37 37.3 99 37 154
Hematologic samples (Various tumors) Various tumors 3.8e-09 37 37.3 99 37 154
Cancer (Liver cancer) Liver cancer 1.7e-08 60 81.0 74 115 207
Cancer and cell line (Various tumors) Various tumors 3.5e-08 83 83.8 99 105 154
Cancer (Various tumors) Various tumors 3.5e-08 83 83.8 99 105 154
Hematologic cancer and cell line (Various tumors) Various tumors 1.4e-07 31 31.3 99 31 154
Hematologic cancer (Various tumors) Various tumors 1.4e-07 31 31.3 99 31 154
Primary blood mononuclear cells (Various tumors) Various tumors 1.4e-07 31 31.3 99 31 154
Lymphocytes (Various tumors) Various tumors 8.4e-07 28 28.2 99 28 154
Monocytes (Various tumors) Various tumors 8.4e-07 28 28.2 99 28 154
Activated B like DLBCL (B lymphoma) B lymphoma 9.7e-07 16 38.0 42 30 245
Diffuse large B cell lymphoma - DLBCL (B lymphoma) B lymphoma 2.9e-06 35 83.3 42 126 245
Cell line (NCI60*) NCI60* 3.3e-06 91 9.6 943 135 1945
Epithelial cell line (NCI60) NCI60 4.8e-06 31 33.6 92 32 139
Breast tissue or cancer (Breast cancer*) Breast cancer* 1.0e-05 42 11.2 373 118 1945
Female hormonal tissue or cancer (Breast cancer*) Breast cancer* 1.0e-05 42 11.2 373 118 1945
Acute lymphocytic leukemia (Leukemia) Leukemia 1.3e-05 85 76.5 111 99 149
B cells (Various tumors) Various tumors 1.3e-05 23 23.2 99 23 154
Cancer and cell line (NCI60*) NCI60* 1.3e-05 91 9.6 943 138 1945
Cancer and cell line (Gliomas*) Gliomas* 1.6e-05 37 3.9 943 47 1945
Cancer (Gliomas*) Gliomas* 1.6e-05 37 3.9 943 47 1945
CNS cancer or cell line (Gliomas*) Gliomas* 1.6e-05 37 3.9 943 47 1945
CNS tissue, cancer or cell line (Gliomas*) Gliomas* 1.6e-05 37 3.9 943 47 1945
CNS tumor (Gliomas*) Gliomas* 1.6e-05 37 3.9 943 47 1945
Liver cancer cell line (Liver cancer) Liver cancer 2.2e-05 10 13.5 74 10 207
Diffuse large B cell lymphoma tumor or cell line (B lymphoma) B lymphoma 2.2e-05 35 83.3 42 134 245
B cells (Leukemia) Leukemia 2.5e-05 56 54.3 103 62 141
Adenocarcinoma (Liver cancer) Liver cancer 2.6e-05 49 66.2 74 97 207
Lymphocytes (Leukemia) Leukemia 4.3e-05 77 74.7 103 91 141
Hepatocellular carcinoma (Liver cancer) Liver cancer 4.8e-05 51 68.9 74 104 207
Breast cancer cell line (Breast cancer) Breast cancer 5.1e-05 14 25.4 55 17 152
Normal female hormonal tissue and cells (Various tumors) Various tumors 5.8e-05 5 41.6 12 8 154
Normal female hormonal tissue (Various tumors) Various tumors 5.8e-05 5 41.6 12 8 154
Lymphoma (Various tumors) Various tumors 6.7e-05 20 20.2 99 20 154
Cell line (Breast cancer) Breast cancer 0.0001 20 36.3 55 30 152
Stage T2 (Lung cancer) Lung cancer 0.0001 10 55.5 18 35 195
Cell line (Liver cancer) Liver cancer 0.0001 10 13.5 74 11 207
Normal tissue (Various tumors) Various tumors 0.0002 10 83.3 12 49 154
Adenocarcinoma (Breast cancer*) Breast cancer* 0.0002 37 9.9 373 112 1945
Breast cancer (Breast cancer*) Breast cancer* 0.0002 37 9.9 373 112 1945
Cancer (Breast cancer*) Breast cancer* 0.0002 37 9.9 373 112 1945
Female hormonal cancer (Breast cancer*) Breast cancer* 0.0002 37 9.9 373 112 1945
Female hormonal cancer cell line (Breast cancer) Breast cancer 0.0003 12 21.8 55 15 152


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation P-value Hits Hits(%) Module genes Genes in annotation Genes
extracellular matrix structural constituent 1.3e-05 23 8.6 267 149 4566
cell adhesion molecule activity 2.5e-05 19 7.1 267 114 4566
cell adhesion 2.7e-05 29 10.8 267 222 4566
coated pit 0.0001 6 2.2 267 15 4566


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Visual display
Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.
You can also view the images within GeneXPress by loading the module gxp file file.
Note: Since there are 1318 experiments, this image does not display the individual experiment names, but rather condenses each experiment to a single pixel without displaying its name. You can fully view the image for this module within GeneXPress, by loading any of the four files mentioned in the line above
 
 





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