Module 263 -- Chemotaxis (chemokines)

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General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets: 4
Num genes: 45 (see 2684 additional genes for this module)
Num experiments: 710 (267 induced, 443 repressed)
Parent module: None
Children modules: 108


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Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
taxis
energy taxis
chemotaxis
chemokine receptor binding


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Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation Category P-value Hits Hits(%) Module hits in category Arrays in annotation Arrays
Lung tissue, cancer or cell line (Lung cancer*) Lung cancer* 5.4e-28 139 31.3 443 276 1945
Cancer and cell line (Lung cancer*) Lung cancer* 1.2e-26 129 29.1 443 252 1945
Cancer (Lung cancer*) Lung cancer* 1.2e-26 129 29.1 443 252 1945
Lung cancer (Lung cancer*) Lung cancer* 1.8e-26 124 27.9 443 238 1945
Lung cancer or cell line (Lung cancer*) Lung cancer* 1.8e-26 124 27.9 443 238 1945
Non-tumor liver tissue (Liver cancer) Liver cancer 1.9e-21 58 79.4 73 76 207
Non small cell lung cancer and cell line (Lung cancer*) Lung cancer* 1.0e-20 104 23.4 443 205 1945
Non small cell lung cancer (Lung cancer*) Lung cancer* 1.0e-20 104 23.4 443 205 1945
Liver tissue (Liver cancer*) Liver cancer* 2.5e-20 73 27.4 266 187 1945
Liver tissue, cancer or cell line (Liver cancer*) Liver cancer* 9.4e-19 73 27.4 266 197 1945
Cancer and cell line (Liver cancer) Liver cancer 4.6e-16 62 98.4 63 126 207
Hepatitis infected liver (Liver cancer*) Liver cancer* 3.2e-14 57 21.4 266 156 1945
Hematologic samples (Stimulated PBMC*) Stimulated PBMC* 4.3e-11 51 19.1 266 152 1945
Lymphocytes (Stimulated PBMC*) Stimulated PBMC* 4.3e-11 51 19.1 266 152 1945
Primary blood mononuclear cells (Stimulated PBMC*) Stimulated PBMC* 4.3e-11 51 19.1 266 152 1945
Acute lymphocytic leukemia (Leukemia) Leukemia 1.3e-09 46 97.8 47 99 149
Lymphocytes (Leukemia) Leukemia 4.6e-09 41 97.6 42 91 141
Hematologic samples and cell lines (Stimulated PBMC*) Stimulated PBMC* 1.9e-08 52 19.5 266 182 1945
Monocytes (Stimulated PBMC*) Stimulated PBMC* 1.9e-08 52 19.5 266 182 1945
Stimulated immune cells (Stimulated PBMC*) Stimulated PBMC* 2.6e-08 44 16.5 266 143 1945
Activated B like DLBCL (B lymphoma) B lymphoma 8.5e-08 15 46.8 32 30 245
Cancer (Liver cancer) Liver cancer 1.1e-07 52 82.5 63 115 207
B cells (Leukemia) Leukemia 5.1e-07 32 76.1 42 62 141
Cell line (Breast cancer) Breast cancer 1.4e-06 16 55.1 29 30 152
Diffuse large B cell lymphoma - DLBCL (B lymphoma) B lymphoma 5.6e-06 28 87.5 32 126 245
Hepatocellular carcinoma (Liver cancer) Liver cancer 1.1e-05 46 73.0 63 104 207
Breast cancer cell line (Breast cancer) Breast cancer 1.1e-05 11 37.9 29 17 152
Bone marrow (Leukemia) Leukemia 1.7e-05 16 38.0 42 23 141
Female hormonal cancer cell line (Breast cancer) Breast cancer 2.3e-05 10 34.4 29 15 152
Diffuse large B cell lymphoma tumor or cell line (B lymphoma) B lymphoma 3.0e-05 28 87.5 32 134 245
Cell line (Liver cancer) Liver cancer 3.3e-05 10 15.8 63 11 207
Adenocarcinoma (Liver cancer) Liver cancer 3.8e-05 43 68.2 63 97 207
Hematologic cancer and cell line (Stimulated PBMC) Stimulated PBMC 8.2e-05 15 39.4 38 30 182
Macrophages (Stimulated PBMC) Stimulated PBMC 8.2e-05 15 39.4 38 30 182
Live bacteria stimulated immune cells (Stimulated PBMC) Stimulated PBMC 9.6e-05 5 20 25 5 148
Liver cancer cell line (Liver cancer) Liver cancer 0.0001 9 14.2 63 10 207
Hematologic cancer and cell line (Stimulated immune*) Stimulated immune* 0.0001 18 6.7 266 53 1945
Hematologic samples and cell lines (Stimulated immune*) Stimulated immune* 0.0001 18 6.7 266 53 1945
Macrophages (Stimulated immune*) Stimulated immune* 0.0001 18 6.7 266 53 1945
Monocytes (Stimulated immune*) Stimulated immune* 0.0001 18 6.7 266 53 1945


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Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation P-value Hits Hits(%) Module genes Genes in annotation Genes
chemotaxis 2.6e-85 44 97.7 45 73 4566
energy taxis 6.5e-85 44 97.7 45 74 4566
taxis 3.7e-84 44 97.7 45 76 4566
chemokine receptor binding 1.0e-67 32 71.1 45 35 4566
inflammatory response 7.5e-51 35 77.7 45 108 4566
thermoregulation 4.6e-49 34 75.5 45 105 4566
receptor binding 8.9e-36 34 75.5 45 235 4566
response to biotic stimulus 1.9e-32 41 91.1 45 600 4566
response to stress 1.9e-27 41 91.1 45 792 4566
immune response 9.5e-27 35 77.7 45 469 4566
cell-cell signaling 1.3e-26 27 60 45 194 4566
signal transducer activity 4.0e-26 43 95.5 45 1026 4566
secretion 5.0e-24 27 60 45 240 4566
calcium ion homeostasis 9.6e-20 11 24.4 45 16 4566
metal ion homeostasis 1.0e-15 11 24.4 45 30 4566
cation homeostasis 1.6e-15 11 24.4 45 31 4566
cell ion homeostasis 3.7e-15 11 24.4 45 33 4566
signal transduction 8.1e-15 32 71.1 45 831 4566
conjugation without cellular fusion 1.5e-14 17 37.7 45 152 4566
G-protein coupled receptor protein signaling pathway 2.5e-13 19 42.2 45 245 4566
cell communication 4.9e-13 33 73.3 45 1030 4566
response to pest/pathogen/parasite 8.8e-13 16 35.5 45 163 4566
binding 3.8e-12 33 73.3 45 1103 4566
extracellular space 3.9e-12 17 37.7 45 212 4566
response to extracellular stimulus 2.0e-11 23 51.1 45 500 4566
peptide receptor activity 4.0e-08 8 17.7 45 55 4566
peptide receptor activity\, G-protein coupled 6.1e-08 8 17.7 45 58 4566
cytosolic calcium ion concentration elevation 7.6e-08 6 13.3 45 24 4566
G-protein signaling\, coupled to IP3 second messenger (phospholipase C activating) 3.0e-07 7 15.5 45 48 4566
response to viruses 5.7e-07 5 11.1 45 18 4566
humoral immune response 1.5e-06 9 20 45 118 4566
heparin binding 1.9e-06 6 13.3 45 40 4566
glycosaminoglycan binding 3.4e-06 6 13.3 45 44 4566
activation of MAPK 3.8e-06 4 8.8 45 12 4566
humoral defense mechanism (sensu Invertebrata) 5.0e-06 7 15.5 45 72 4566
cellular defense response 7.4e-06 6 13.3 45 50 4566
G-protein chemoattractant receptor activity 7.6e-06 4 8.8 45 14 4566
rhodopsin-like receptor activity 9.5e-06 9 20 45 147 4566
cell motility 1.1e-05 8 17.7 45 113 4566
G-protein coupled receptor activity 3.1e-05 9 20 45 170 4566
MAPKKK cascade (osmolarity sensing) 4.3e-05 4 8.8 45 21 4566
sensory perception 5.0e-05 18 40 45 700 4566
MAPKKK cascade 8.9e-05 4 8.8 45 25 4566
viral replication 0.0001 3 6.6 45 10 4566
two-component signal transduction system (phosphorelay) 0.0001 4 8.8 45 26 4566


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Visual display
Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.
You can also view the images within GeneXPress by loading the module gxp file file.
Note: Since there are 710 experiments, this image does not display the individual experiment names, but rather condenses each experiment to a single pixel without displaying its name. You can fully view the image for this module within GeneXPress, by loading any of the four files mentioned in the line above
 
 





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