Module 265 -- IL receptors

Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets: 3
Num genes: 29 (see 1919 additional genes for this module)
Num experiments: 273 (123 induced, 150 repressed)
Parent module: None
Children modules: 73


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
interleukin receptor activity
interleukin binding
hematopoietin/interferon_class (D200_domain) cytokine receptor activity


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation Category P-value Hits Hits(%) Module hits in category Arrays in annotation Arrays
Liver tissue (Liver cancer*) Liver cancer* 1.2e-16 44 35.7 123 187 1945
Liver tissue, cancer or cell line (Liver cancer*) Liver cancer* 1.0e-15 44 35.7 123 197 1945
Hepatitis infected liver (Liver cancer*) Liver cancer* 3.5e-13 36 29.2 123 156 1945
Non-tumor liver tissue (Liver cancer) Liver cancer 6.4e-11 35 79.5 44 76 207
Hematologic cancer and cell line (Stimulated PBMC) Stimulated PBMC 5.3e-10 17 65.3 26 30 182
Macrophages (Stimulated PBMC) Stimulated PBMC 5.3e-10 17 65.3 26 30 182
Cancer and cell line (Liver cancer) Liver cancer 2.1e-08 32 100 32 126 207
Liver cancer cell line (Liver cancer) Liver cancer 5.1e-06 8 25 32 10 207
Normal lung tissue (Lung cancer) Lung cancer 6.0e-06 9 40.9 22 22 276
Normal tissue (Lung cancer) Lung cancer 9.5e-06 9 40.9 22 23 276
Hematologic cancer and cell line (Stimulated immune*) Stimulated immune* 1.3e-05 13 10.5 123 53 1945
Hematologic samples and cell lines (Stimulated immune*) Stimulated immune* 1.3e-05 13 10.5 123 53 1945
Macrophages (Stimulated immune*) Stimulated immune* 1.3e-05 13 10.5 123 53 1945
Monocytes (Stimulated immune*) Stimulated immune* 1.3e-05 13 10.5 123 53 1945
Cell line (Liver cancer) Liver cancer 1.6e-05 8 25 32 11 207
Hematologic cancer and cell line (Stimulated immune*) Stimulated immune* 2.2e-05 14 9.3 149 53 1945
Hematologic samples and cell lines (Stimulated immune*) Stimulated immune* 2.2e-05 14 9.3 149 53 1945
Macrophages (Stimulated immune*) Stimulated immune* 2.2e-05 14 9.3 149 53 1945
Monocytes (Stimulated immune*) Stimulated immune* 2.2e-05 14 9.3 149 53 1945
Activated B like DLBCL (B lymphoma) B lymphoma 4.8e-05 7 63.6 11 30 245
Cell line (B lymphoma) B lymphoma 6.0e-05 5 50 10 14 245
Metastasis (Liver cancer) Liver cancer 9.7e-05 7 21.8 32 10 207
Cell line (Breast cancer) Breast cancer 0.0002 8 66.6 12 30 152
Live bacteria stimulated immune cells (Stimulated PBMC) Stimulated PBMC 0.0003 4 26.6 15 5 148
Primary blood mononuclear cells (Leukemia) Leukemia 0.0004 9 45 20 21 141


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation P-value Hits Hits(%) Module genes Genes in annotation Genes
hematopoietin/interferon-class (D200-domain) cytokine receptor activity 1.8e-65 29 100 29 42 4566
interleukin receptor activity 3.7e-45 21 72.4 29 28 4566
interleukin binding 1.3e-40 19 65.5 29 25 4566
transmembrane receptor activity 2.4e-30 29 100 29 448 4566
receptor activity 6.1e-27 29 100 29 582 4566
transmembrane receptor protein tyrosine kinase activity 1.0e-19 14 48.2 29 62 4566
signal transducer activity 1.1e-19 29 100 29 1026 4566
transmembrane receptor protein kinase activity 4.2e-19 14 48.2 29 68 4566
protein kinase activity 1.8e-16 14 48.2 29 102 4566
interleukin-1\, Type I\, activating receptor activity 1.9e-16 7 24.1 29 7 4566
interleukin-1 receptor activity 1.5e-15 7 24.1 29 8 4566
protein tyrosine kinase activity 1.9e-15 14 48.2 29 120 4566
porin activity 1.2e-12 15 51.7 29 235 4566
response to biotic stimulus 5.5e-12 20 68.9 29 600 4566
immune response 1.4e-11 18 62.0 29 469 4566
channel/pore class transporter activity 4.1e-10 15 51.7 29 351 4566
response to stress 1.0e-09 20 68.9 29 792 4566
integral to plasma membrane 1.2e-09 18 62.0 29 612 4566
signal transduction 2.3e-08 19 65.5 29 831 4566
cell communication 8.5e-07 19 65.5 29 1030 4566
inflammatory response 3.4e-06 7 24.1 29 108 4566
cell surface receptor linked signal transduction 1.9e-05 9 31.0 29 259 4566
thermoregulation 3.9e-05 6 20.6 29 105 4566


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Visual display
Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.
You can also view the images within GeneXPress by loading the module gxp file file.
 
 





 >4x