Module 27

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General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets: 2
Num genes: 356 (see 3065 additional genes for this module)
Num experiments: 914 (331 induced, 583 repressed)
Parent module: 64
Children modules: None


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
transmembrane receptor activity
receptor activity


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation Category P-value Hits Hits(%) Module hits in category Arrays in annotation Arrays
Acute leukemia (Leukemia*) Leukemia* 5.8e-41 116 19.9 582 141 1945
Cancer and cell line (Leukemia*) Leukemia* 5.8e-41 116 19.9 582 141 1945
Cancer (Leukemia*) Leukemia* 5.8e-41 116 19.9 582 141 1945
Hematologic cancer and cell line (Leukemia*) Leukemia* 5.8e-41 116 19.9 582 141 1945
Hematologic cancer (Leukemia*) Leukemia* 5.8e-41 116 19.9 582 141 1945
Hematologic samples and cell lines (Leukemia*) Leukemia* 5.8e-41 116 19.9 582 141 1945
Leukemia (Leukemia*) Leukemia* 5.8e-41 116 19.9 582 141 1945
Leukemia or leukemia cell line (Leukemia*) Leukemia* 5.8e-41 116 19.9 582 141 1945
Monocytes (Leukemia*) Leukemia* 5.8e-41 116 19.9 582 141 1945
Non-tumor liver tissue (Liver cancer) Liver cancer 9.7e-29 71 75.5 94 76 207
Liver tissue (Liver cancer*) Liver cancer* 3.7e-28 93 28.0 331 187 1945
Liver tissue, cancer or cell line (Liver cancer*) Liver cancer* 6.6e-26 93 28.0 331 197 1945
Cancer and cell line (Liver cancer) Liver cancer 1.1e-25 86 98.8 87 126 207
Hepatitis infected liver (Liver cancer*) Liver cancer* 9.1e-20 73 22.0 331 156 1945
Hematologic cancer and cell line (Stimulated PBMC) Stimulated PBMC 6.0e-15 22 70.9 31 30 182
Macrophages (Stimulated PBMC) Stimulated PBMC 6.0e-15 22 70.9 31 30 182
Cancer (Liver cancer) Liver cancer 6.9e-15 75 86.2 87 115 207
Hematologic samples and cell lines (B lymphoma) B lymphoma 1.3e-13 69 81.1 85 121 245
Adenocarcinoma (Liver cancer) Liver cancer 4.6e-12 65 74.7 87 97 207
Hepatocellular carcinoma (Liver cancer) Liver cancer 2.9e-11 67 77.0 87 104 207
Lymphoma (B lymphoma) B lymphoma 1.3e-09 48 56.4 85 77 245
Activated B like DLBCL (B lymphoma) B lymphoma 4.8e-08 15 48.3 31 30 245
Invasive liver tumor (Liver cancer) Liver cancer 3.6e-07 30 34.4 87 38 207
Breast tissue or cancer (Breast cancer*) Breast cancer* 3.1e-06 40 12.0 331 118 1945
Female hormonal tissue or cancer (Breast cancer*) Breast cancer* 3.1e-06 40 12.0 331 118 1945
Breast cancer cell line (Breast cancer) Breast cancer 3.5e-06 14 30.4 46 17 152
Cell line (Breast cancer) Breast cancer 4.0e-06 20 43.4 46 30 152
Cell line (B lymphoma) B lymphoma 5.5e-06 13 15.2 85 14 245
Lung carcinoid (Lung cancer) Lung cancer 7.1e-06 14 21.2 66 20 276
Hematologic samples (Stimulated PBMC*) Stimulated PBMC* 1.8e-05 46 13.8 331 152 1945
Lymphocytes (Stimulated PBMC*) Stimulated PBMC* 1.8e-05 46 13.8 331 152 1945
Primary blood mononuclear cells (Stimulated PBMC*) Stimulated PBMC* 1.8e-05 46 13.8 331 152 1945
Fast doubling (20-40) cell lines (NCI60) NCI60 3.4e-05 35 97.2 36 90 122
Adenocarcinoma (Breast cancer*) Breast cancer* 3.9e-05 36 10.8 331 112 1945
Breast cancer (Breast cancer*) Breast cancer* 3.9e-05 36 10.8 331 112 1945
Cancer (Breast cancer*) Breast cancer* 3.9e-05 36 10.8 331 112 1945
Female hormonal cancer (Breast cancer*) Breast cancer* 3.9e-05 36 10.8 331 112 1945
Female hormonal cancer cell line (Breast cancer) Breast cancer 4.0e-05 12 26.0 46 15 152
Cell line (Liver cancer) Liver cancer 4.8e-05 11 12.6 87 11 207
B. petrussis A2 stimulated immune cells (Stimulated PBMC) Stimulated PBMC 5.4e-05 5 22.7 22 5 144
Liver cancer cell line (Liver cancer) Liver cancer 0.0001 10 11.4 87 10 207
Normal tissue (Liver cancer) Liver cancer 0.0001 13 13.8 94 14 207
Hematologic cancer and cell line (Stimulated immune*) Stimulated immune* 0.0002 20 6.0 331 53 1945
Hematologic samples and cell lines (Stimulated immune*) Stimulated immune* 0.0002 20 6.0 331 53 1945
Macrophages (Stimulated immune*) Stimulated immune* 0.0002 20 6.0 331 53 1945
Monocytes (Stimulated immune*) Stimulated immune* 0.0002 20 6.0 331 53 1945
Female hormonal tissue, cancer or cell line (Breast cancer*) Breast cancer* 0.0003 40 12.0 331 141 1945
Diffuse large B cell lymphoma - DLBCL (B lymphoma) B lymphoma 0.0003 25 80.6 31 126 245
Breast tissue, cancer or cell line (Breast cancer*) Breast cancer* 0.0003 40 12.0 331 142 1945


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation P-value Hits Hits(%) Module genes Genes in annotation Genes
receptor activity 0 356 100 356 582 4566
transmembrane receptor activity 1.7e-271 290 81.4 356 448 4566
signal transducer activity 1.5e-182 321 90.1 356 1026 4566
integral to plasma membrane 3.8e-107 214 60.1 356 612 4566
porin activity 3.1e-103 140 39.3 356 235 4566
channel/pore class transporter activity 1.7e-95 160 44.9 356 351 4566
G-protein coupled receptor activity 9.8e-71 100 28.0 356 170 4566
rhodopsin-like receptor activity 4.9e-60 86 24.1 356 147 4566
signal transduction 3.5e-59 194 54.4 356 831 4566
cell communication 7.9e-57 213 59.8 356 1030 4566
cell surface receptor linked signal transduction 2.6e-42 94 26.4 356 259 4566
transmembrane receptor protein tyrosine kinase activity 1.4e-40 47 13.2 356 62 4566
transmembrane receptor protein kinase activity 6.1e-39 48 13.4 356 68 4566
response to biotic stimulus 1.2e-37 138 38.7 356 600 4566
response to stress 3.7e-35 157 44.1 356 792 4566
protein kinase activity 3.6e-34 54 15.1 356 102 4566
G-protein coupled receptor protein signaling pathway 9.8e-33 81 22.7 356 245 4566
immune response 4.0e-29 109 30.6 356 469 4566
conjugation without cellular fusion 5.6e-28 59 16.5 356 152 4566
hematopoietin/interferon-class (D200-domain) cytokine receptor activity 2.4e-26 31 8.7 356 42 4566
peptide receptor activity\, G-protein coupled 2.7e-26 36 10.1 356 58 4566
peptide receptor activity 8.7e-25 34 9.5 356 55 4566
immunoglobulin receptor activity 2.9e-20 21 5.8 356 25 4566
interleukin receptor activity 2.1e-18 21 5.8 356 28 4566
interleukin binding 6.4e-17 19 5.3 356 25 4566
eye photoreceptor cell fate commitment 8.6e-17 23 6.4 356 38 4566
glutamate receptor activity 1.1e-16 24 6.7 356 42 4566
extracellular ligand-gated ion channel activity 4.5e-16 21 5.8 356 33 4566
transmembrane receptor protein tyrosine kinase signaling pathway 4.8e-16 26 7.3 356 52 4566
compound eye morphogenesis (sensu Drosophila) 9.0e-16 23 6.4 356 41 4566
post-embryonic morphogenesis 9.0e-16 23 6.4 356 41 4566
post-embryonic development 1.8e-15 23 6.4 356 42 4566
G-protein signaling\, coupled to cyclic nucleotide second messenger 8.3e-15 26 7.3 356 57 4566
amine receptor activity 1.3e-14 19 5.3 356 30 4566
cell adhesion receptor activity 2.1e-14 17 4.7 356 24 4566
excitatory extracellular ligand-gated ion channel activity 5.2e-14 15 4.2 356 19 4566
protein tyrosine kinase activity 5.4e-14 37 10.3 356 120 4566
integrin complex 1.9e-13 15 4.2 356 20 4566
defense response 2.2e-13 58 16.2 356 272 4566
response to extracellular stimulus 2.7e-13 85 23.8 356 500 4566
ligand-gated ion channel activity 9.3e-13 22 6.1 356 48 4566
synaptic transmission 3.1e-12 34 9.5 356 116 4566
G-protein signaling\, coupled to IP3 second messenger (phospholipase C activating) 9.5e-12 21 5.8 356 48 4566
defense/immunity protein activity 1.3e-11 31 8.7 356 103 4566
vesicle-mediated transport 4.1e-11 44 12.3 356 196 4566
scavenger receptor activity 9.6e-11 9 2.5 356 9 4566
integrin-mediated signaling pathway 1.0e-10 14 3.9 356 23 4566
cellular defense response 2.1e-10 20 5.6 356 50 4566
cytosolic calcium ion concentration elevation 2.2e-10 14 3.9 356 24 4566
cell-matrix adhesion 5.0e-10 15 4.2 356 29 4566
Fc receptor activity 9.0e-10 9 2.5 356 10 4566
nicotinic acetylcholine-activated cation-selective channel activity 9.0e-10 9 2.5 356 10 4566
cAMP-mediated signaling 1.7e-09 15 4.2 356 31 4566
transmembrane receptor protein phosphatase activity 1.7e-09 10 2.8 356 13 4566
antigen presentation\, peptide antigen 5.5e-09 10 2.8 356 14 4566
antigen processing 5.5e-09 10 2.8 356 14 4566
G-protein signaling\, coupled to cAMP nucleotide second messenger 9.5e-09 16 4.4 356 39 4566
acetylcholine receptor activity 1.0e-08 8 2.2 356 9 4566
nicotinic acetylcholine-gated receptor-channel complex 1.0e-08 8 2.2 356 9 4566
nucleotide receptor activity 1.5e-08 10 2.8 356 15 4566
ion channel activity 4.1e-08 28 7.8 356 117 4566
neurotransmitter receptor activity 4.9e-08 11 3.0 356 20 4566
coreceptor activity 4.9e-08 8 2.2 356 10 4566
ligand-dependent nuclear receptor activity 6.8e-08 13 3.6 356 29 4566
cell adhesion 8.9e-08 41 11.5 356 222 4566
inflammatory response 1.1e-07 26 7.3 356 108 4566
G-protein chemoattractant receptor activity 1.3e-07 9 2.5 356 14 4566
ephrin receptor activity 1.6e-07 8 2.2 356 11 4566
thermoregulation 2.5e-07 25 7.0 356 105 4566
MHC class I receptor activity 5.1e-07 7 1.9 356 9 4566
response to pest/pathogen/parasite 6.2e-07 32 8.9 356 163 4566
G-protein signaling\, adenylate cyclase inhibiting pathway 6.7e-07 9 2.5 356 16 4566
alpha-type channel activity 7.4e-07 28 7.8 356 133 4566
T-cell activation 9.3e-07 37 10.3 356 207 4566
lymphocyte activation 1.1e-06 37 10.3 356 209 4566
GABA-A receptor activity 1.3e-06 9 2.5 356 17 4566
antigen binding 1.4e-06 6 1.6 356 7 4566
steroid hormone receptor activity 1.4e-06 11 3.0 356 26 4566
chemokine binding 4.1e-06 7 1.9 356 11 4566
sugar binding 4.2e-06 15 4.2 356 51 4566
protein amino acid phosphorylation 4.9e-06 38 10.6 356 230 4566
antigen presentation\, endogenous antigen 5.2e-06 6 1.6 356 8 4566
antigen processing\, endogenous antigen via MHC class I 5.2e-06 6 1.6 356 8 4566
carbohydrate binding 5.5e-06 15 4.2 356 52 4566
humoral defense mechanism (sensu Invertebrata) 6.0e-06 18 5.0 356 72 4566
endocytosis 7.4e-06 13 3.6 356 41 4566
activation of MAPK 9.2e-06 7 1.9 356 12 4566
GPI-anchored membrane-bound receptor 1.4e-05 6 1.6 356 9 4566
receptor mediated endocytosis 1.8e-05 7 1.9 356 13 4566
humoral immune response 2.8e-05 23 6.4 356 118 4566
negative regulation of adenylate cyclase activity 3.4e-05 6 1.6 356 10 4566
sensory perception 4.2e-05 82 23.0 356 700 4566
interleukin-1\, Type I\, activating receptor activity 5.1e-05 5 1.4 356 7 4566
taxis 5.2e-05 17 4.7 356 76 4566
MAPKKK cascade 6.3e-05 9 2.5 356 25 4566
induction of programmed cell death 8.7e-05 20 5.6 356 102 4566
heterophilic cell adhesion 8.9e-05 12 3.3 356 44 4566
two-component signal transduction system (phosphorelay) 9.1e-05 9 2.5 356 26 4566
chemotaxis 0.0001 16 4.4 356 73 4566
death 0.0001 46 12.9 356 342 4566
interleukin-1 receptor activity 0.0001 5 1.4 356 8 4566
response to water 0.0001 5 1.4 356 8 4566
metabotropic glutamate\, GABA-B-like receptor activity 0.0001 6 1.6 356 12 4566
secretin-like receptor activity 0.0001 6 1.6 356 12 4566


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Visual display
Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.
You can also view the images within GeneXPress by loading the module gxp file file.
Note: Since there are 914 experiments, this image does not display the individual experiment names, but rather condenses each experiment to a single pixel without displaying its name. You can fully view the image for this module within GeneXPress, by loading any of the four files mentioned in the line above
 
 





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