Module 320 -- M phase

Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets: 3
Num genes: 20 (see 1124 additional genes for this module)
Num experiments: 183 (98 induced, 85 repressed)
Parent module: 397
Children modules: None


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
nuclear division
M phase
M phase of mitotic cell cycle


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation Category P-value Hits Hits(%) Module hits in category Arrays in annotation Arrays
Hematologic cancer and cell line (Stimulated PBMC) Stimulated PBMC 4.1e-15 16 100 16 30 182
Macrophages (Stimulated PBMC) Stimulated PBMC 4.1e-15 16 100 16 30 182
Non-tumor liver tissue (Liver cancer) Liver cancer 2.4e-14 30 96.7 31 76 207
Liver tissue (Liver cancer*) Liver cancer* 4.4e-12 31 36.4 85 187 1945
Liver tissue, cancer or cell line (Liver cancer*) Liver cancer* 1.9e-11 31 36.4 85 197 1945
Liver cancer cell line (Liver cancer) Liver cancer 6.1e-11 10 41.6 24 10 207
Cell line (Liver cancer) Liver cancer 6.3e-10 10 41.6 24 11 207
Cancer and cell line (Fibroblast EWS-FLI*) Fibroblast EWS-FLI* 1.0e-06 6 7.0 85 10 1945
Cell line (Fibroblast EWS-FLI*) Fibroblast EWS-FLI* 1.0e-06 6 7.0 85 10 1945
EWS/FLI expressing fibroblasts (Fibroblast EWS-FLI*) Fibroblast EWS-FLI* 1.0e-06 6 7.0 85 10 1945
Fibroblasts (Fibroblast EWS-FLI*) Fibroblast EWS-FLI* 1.0e-06 6 7.0 85 10 1945
Skin fibroblasts (Fibroblast EWS-FLI*) Fibroblast EWS-FLI* 1.0e-06 6 7.0 85 10 1945
Hepatitis infected liver (Liver cancer*) Liver cancer* 1.2e-06 21 24.7 85 156 1945
Cancer and cell line (Liver cancer) Liver cancer 2.5e-06 24 100 24 126 207
Normal tissue (Liver cancer) Liver cancer 1.4e-05 9 29.0 31 14 207
Small cell lung cancer (Lung cancer) Lung cancer 2.2e-05 5 38.4 13 10 276
Liver tissue, cancer or cell line (Liver cancer*) Liver cancer* 6.0e-05 23 23.4 98 197 1945
Centroblasts (Various tumors) Various tumors 6.6e-05 3 75 4 5 154
GC B like DLBCL (Various tumors) Various tumors 6.6e-05 3 75 4 5 154
Follicular lymphoma (B lymphoma) B lymphoma 0.0002 6 60 10 28 245
Normal lung tissue (Lung cancer) Lung cancer 0.0002 5 55.5 9 22 276
Normal tissue (Lung cancer) Lung cancer 0.0002 5 55.5 9 23 276


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation P-value Hits Hits(%) Module genes Genes in annotation Genes
M phase 3.7e-50 20 100 20 26 4566
nuclear division 1.4e-38 16 80 20 20 4566
cell cycle 6.1e-32 20 100 20 135 4566
M phase of mitotic cell cycle 3.0e-30 13 65 20 17 4566
mitotic cell cycle 8.1e-27 15 75 20 51 4566
mitosis 1.8e-24 14 70 20 50 4566
mitotic anaphase 4.4e-18 8 40 20 11 4566
regulation of transcription 4.3e-10 8 40 20 76 4566
transcription\, DNA-dependent 4.4e-10 10 50 20 167 4566
transcription 1.1e-09 10 50 20 184 4566
meiosis 3.3e-08 4 20 20 9 4566
chromosome segregation 7.1e-07 3 15 20 5 4566
regulation of transcription\, DNA-dependent 1.0e-06 12 60 20 595 4566
cytokinesis 1.5e-06 5 25 20 49 4566
nucleus 3.5e-06 14 70 20 966 4566
microtubule cytoskeleton organization and biogenesis 1.1e-05 3 15 20 11 4566
spindle 3.1e-05 3 15 20 15 4566
DNA repair 3.8e-05 5 25 20 93 4566
microtubule associated complex 5.5e-05 6 30 20 167 4566
endomembrane system 5.5e-05 13 65 20 1029 4566
DNA metabolism 5.9e-05 6 30 20 169 4566
microtubule cytoskeleton 7.4e-05 6 30 20 176 4566
cytoskeleton 7.8e-05 7 35 20 263 4566


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Visual display
Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.
You can also view the images within GeneXPress by loading the module gxp file file.
 
 





 >4x