Module 371

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General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets: 5
Num genes: 26 (see 649 additional genes for this module)
Num experiments: 137 (63 induced, 74 repressed)
Parent module: None
Children modules: 280 281


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
zinc ion binding
transition metal ion binding
protein phosphatase regulator activity
phosphatase regulator activity
single_stranded DNA binding


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation Category P-value Hits Hits(%) Module hits in category Arrays in annotation Arrays
Hematologic cancer and cell line (Stimulated immune*) Stimulated immune* 6.6e-14 17 26.9 63 53 1945
Hematologic samples and cell lines (Stimulated immune*) Stimulated immune* 6.6e-14 17 26.9 63 53 1945
Macrophages (Stimulated immune*) Stimulated immune* 6.6e-14 17 26.9 63 53 1945
Monocytes (Stimulated immune*) Stimulated immune* 6.6e-14 17 26.9 63 53 1945
Hematologic cancer and cell line (Stimulated immune*) Stimulated immune* 2.8e-09 14 18.9 74 53 1945
Hematologic samples and cell lines (Stimulated immune*) Stimulated immune* 2.8e-09 14 18.9 74 53 1945
Macrophages (Stimulated immune*) Stimulated immune* 2.8e-09 14 18.9 74 53 1945
Monocytes (Stimulated immune*) Stimulated immune* 2.8e-09 14 18.9 74 53 1945
Hematologic samples (Stimulated PBMC*) Stimulated PBMC* 6.1e-08 21 28.3 74 152 1945
Lymphocytes (Stimulated PBMC*) Stimulated PBMC* 6.1e-08 21 28.3 74 152 1945
Primary blood mononuclear cells (Stimulated PBMC*) Stimulated PBMC* 6.1e-08 21 28.3 74 152 1945
Stimulated immune cells (Stimulated PBMC*) Stimulated PBMC* 5.8e-07 19 25.6 74 143 1945
Hematologic samples and cell lines (Stimulated PBMC*) Stimulated PBMC* 1.4e-06 21 28.3 74 182 1945
Monocytes (Stimulated PBMC*) Stimulated PBMC* 1.4e-06 21 28.3 74 182 1945
Breast tissue or cancer (NCI60) NCI60 3.6e-05 3 75 4 4 139
Female hormonal tissue or cancer (NCI60) NCI60 3.6e-05 3 75 4 4 139
Diffuse large B cell lymphoma - DLBCL (B lymphoma) B lymphoma 6.2e-05 14 100 14 126 245
Diffuse large B cell lymphoma tumor or cell line (B lymphoma) B lymphoma 0.0001 14 100 14 134 245
Node in lung (Lung cancer) Lung cancer 0.0002 3 33.3 9 5 276


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation P-value Hits Hits(%) Module genes Genes in annotation Genes
transition metal ion binding 5.1e-13 13 50 26 160 4566
metalloendopeptidase activity 1.2e-12 9 34.6 26 46 4566
collagen catabolism 3.0e-11 6 23.0 26 13 4566
metallopeptidase activity 7.0e-11 9 34.6 26 70 4566
zinc ion binding 1.3e-10 10 38.4 26 108 4566
single-stranded DNA binding 6.7e-10 6 23.0 26 20 4566
protein catabolism 1.7e-09 6 23.0 26 23 4566
macromolecule catabolism 3.0e-09 6 23.0 26 25 4566
binding 1.9e-08 20 76.9 26 1103 4566
protein phosphatase regulator activity 4.5e-08 7 26.9 26 65 4566
phosphatase regulator activity 5.0e-08 7 26.9 26 66 4566
metal ion binding 7.1e-08 13 50 26 410 4566
enzyme activator activity 9.7e-08 6 23.0 26 43 4566
proteolysis and peptidolysis 2.7e-07 9 34.6 26 176 4566
peptidase activity 5.9e-07 9 34.6 26 193 4566
endopeptidase activity 8.5e-07 7 26.9 26 99 4566
replication fork 0.0001 3 11.5 26 17 4566
extracellular space 0.0001 7 26.9 26 212 4566


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Visual display
Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.
You can also view the images within GeneXPress by loading the module gxp file file.
 
 





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