Module 373 -- Oxidoreductases

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General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets: 5
Num genes: 22 (see 1215 additional genes for this module)
Num experiments: 356 (115 induced, 241 repressed)
Parent module: None
Children modules: 287


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Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
Tyrosine_metabolism
Histidine_metabolism
vision
perception of light
oxidoreductase activity, acting on the CH_NH2 group of donors


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Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation Category P-value Hits Hits(%) Module hits in category Arrays in annotation Arrays
Cancer and cell line (Lung cancer*) Lung cancer* 1.5e-83 145 60.1 241 252 1945
Cancer (Lung cancer*) Lung cancer* 1.5e-83 145 60.1 241 252 1945
Lung tissue, cancer or cell line (Lung cancer*) Lung cancer* 2.2e-78 147 60.9 241 276 1945
Lung cancer (Lung cancer*) Lung cancer* 1.6e-72 133 55.1 241 238 1945
Lung cancer or cell line (Lung cancer*) Lung cancer* 1.6e-72 133 55.1 241 238 1945
Non small cell lung cancer and cell line (Lung cancer*) Lung cancer* 4.2e-62 116 48.1 241 205 1945
Non small cell lung cancer (Lung cancer*) Lung cancer* 4.2e-62 116 48.1 241 205 1945
Liver tissue (Liver cancer*) Liver cancer* 8.1e-46 69 60.5 114 187 1945
Liver tissue, cancer or cell line (Liver cancer*) Liver cancer* 5.3e-44 69 60.5 114 197 1945
Hepatitis infected liver (Liver cancer*) Liver cancer* 2.9e-31 53 46.4 114 156 1945
Cancer and cell line (Liver cancer) Liver cancer 1.2e-10 40 100 40 126 207
Hematologic samples and cell lines (Various tumors) Various tumors 1.0e-08 21 65.6 32 37 154
Hematologic samples (Various tumors) Various tumors 1.0e-08 21 65.6 32 37 154
Non-tumor liver tissue (Liver cancer) Liver cancer 1.5e-08 44 63.7 69 76 207
Metastasis (Liver cancer) Liver cancer 2.6e-08 10 25 40 10 207
Liver cancer cell line (Liver cancer) Liver cancer 1.4e-06 9 22.5 40 10 207
Hematologic cancer and cell line (Various tumors) Various tumors 1.7e-06 17 53.1 32 31 154
Hematologic cancer (Various tumors) Various tumors 1.7e-06 17 53.1 32 31 154
Primary blood mononuclear cells (Various tumors) Various tumors 1.7e-06 17 53.1 32 31 154
Cell line (Liver cancer) Liver cancer 6.8e-06 9 22.5 40 11 207
Lymphocytes (Various tumors) Various tumors 1.6e-05 15 46.8 32 28 154
Monocytes (Various tumors) Various tumors 1.6e-05 15 46.8 32 28 154
Normal tissue (Various tumors) Various tumors 4.4e-05 10 90.9 11 49 154
Cancer and cell line (Various tumors*) Various tumors* 9.3e-05 27 11.2 241 105 1945
Cancer (Various tumors*) Various tumors* 9.3e-05 27 11.2 241 105 1945
Colon cancer (Liver cancer) Liver cancer 0.0002 5 12.5 40 5 207
Colon cancer metastasis to liver (Liver cancer) Liver cancer 0.0002 5 12.5 40 5 207
Colon cancer or cell line (Liver cancer) Liver cancer 0.0002 5 12.5 40 5 207
Colon tissue, cancer or cell line (Liver cancer) Liver cancer 0.0002 5 12.5 40 5 207
B cells (Various tumors) Various tumors 0.0002 12 37.5 32 23 154


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation P-value Hits Hits(%) Module genes Genes in annotation Genes
oxidoreductase activity 2.1e-17 16 80 20 254 4566
electron transporter activity 2.9e-15 15 75 20 269 4566
alcohol metabolism 9.0e-12 6 30 20 14 4566
oxidoreductase activity\, acting on the aldehyde or oxo group of donors 3.7e-11 6 30 20 17 4566
aldehyde dehydrogenase activity 2.3e-10 5 25 20 10 4566
amine oxidase activity 1.3e-09 4 20 20 5 4566
oxidoreductase activity\, acting on the aldehyde or oxo group of donors\, NAD or NADP as acceptor 1.8e-09 5 25 20 14 4566
catalytic activity 1.8e-09 20 100 20 1677 4566
xenobiotic metabolism 6.6e-09 6 30 20 37 4566
oxidoreductase activity\, acting on the CH-NH2 group of donors\, oxygen as acceptor 1.8e-08 4 20 20 8 4566
oxidoreductase activity\, acting on the CH-NH2 group of donors 3.3e-08 4 20 20 9 4566
response to xenobiotic stimulus 3.9e-08 8 40 20 133 4566
alcohol dehydrogenase activity\, zinc-dependent 5.5e-08 4 20 20 10 4566
alcohol dehydrogenase activity 1.2e-07 4 20 20 12 4566
amine metabolism 1.4e-07 5 25 20 31 4566
response to chemical substance 1.7e-07 10 50 20 308 4566
carboxylic acid metabolism 1.1e-06 7 35 20 138 4566
organic acid metabolism 1.1e-06 7 35 20 139 4566
oxidoreductase activity\, acting on CH-OH group of donors 2.3e-06 5 25 20 53 4566
oxidoreductase activity\, acting on the CH-OH group of donors\, NAD or NADP as acceptor 2.3e-06 5 25 20 53 4566
transition metal ion binding 3.0e-06 7 35 20 160 4566
amino acid and derivative metabolism 3.7e-06 4 20 20 26 4566
aldehyde metabolism 8.4e-06 3 15 20 10 4566


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Visual display
Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.
You can also view the images within GeneXPress by loading the module gxp file file.
 
 





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