Module 512 -- Muscle genes

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General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets: 10
Num genes: 37 (see 520 additional genes for this module)
Num experiments: 213 (64 induced, 149 repressed)
Parent module: None
Children modules: 387


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
muscle development
muscle contraction
structural constituent of muscle
striated muscle thick filament
striated muscle contraction
sarcomere
muscle fiber
actin filament_based process
actin filament_based movement
Staunton01 48


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Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation Category P-value Hits Hits(%) Module hits in category Arrays in annotation Arrays
Lymphoma (B lymphoma) B lymphoma 1.3e-50 69 98.5 70 77 245
Cancer (B lymphoma*) B lymphoma* 3.0e-34 70 46.9 149 200 1945
Hematologic cancer (B lymphoma*) B lymphoma* 3.0e-34 70 46.9 149 200 1945
Cancer and cell line (B lymphoma*) B lymphoma* 5.0e-32 70 46.9 149 214 1945
Hematologic cancer and cell line (B lymphoma*) B lymphoma* 5.0e-32 70 46.9 149 214 1945
B cells (B lymphoma*) B lymphoma* 1.3e-29 70 46.9 149 231 1945
Lymphocytes (B lymphoma*) B lymphoma* 7.0e-28 70 46.9 149 244 1945
Hematologic samples and cell lines (B lymphoma) B lymphoma 2.8e-26 69 98.5 70 121 245
Lymphoma or lymphoma cell line (B lymphoma) B lymphoma 5.1e-15 70 100 70 167 245
Diffuse large B cell lymphoma - DLBCL (B lymphoma) B lymphoma 2.1e-07 54 77.1 70 126 245
Diffuse large B cell lymphoma tumor or cell line (B lymphoma) B lymphoma 5.0e-06 54 77.1 70 134 245
Breast tissue or cancer (Breast cancer*) Breast cancer* 0.0002 12 19.0 63 118 1945
Female hormonal tissue or cancer (Breast cancer*) Breast cancer* 0.0002 12 19.0 63 118 1945
Cell line (Breast cancer) Breast cancer 0.0003 9 60 15 30 152
Female hormonal tissue, cancer or cell line (Breast cancer*) Breast cancer* 0.0003 13 20.6 63 141 1945
Breast tissue, cancer or cell line (Breast cancer*) Breast cancer* 0.0004 13 20.6 63 142 1945


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation P-value Hits Hits(%) Module genes Genes in annotation Genes
muscle contraction 1.6e-42 27 72.9 37 76 4566
muscle development 6.8e-27 19 51.3 37 65 4566
actin filament-based movement 9.0e-23 15 40.5 37 41 4566
actin filament-based process 1.0e-21 15 40.5 37 47 4566
cytoskeleton organization and biogenesis 1.4e-17 15 40.5 37 83 4566
striated muscle contraction 2.8e-17 10 27.0 37 19 4566
organogenesis 1.8e-14 20 54.0 37 315 4566
morphogenesis 2.1e-14 21 56.7 37 366 4566
development 6.5e-13 23 62.1 37 554 4566
structural constituent of muscle 2.4e-12 8 21.6 37 22 4566
actin cytoskeleton 2.1e-11 11 29.7 37 83 4566
cell motility 3.2e-11 12 32.4 37 113 4566
muscle fiber 3.0e-10 9 24.3 37 56 4566
sarcomere 2.9e-09 8 21.6 37 49 4566
striated muscle thick filament 3.2e-09 5 13.5 37 9 4566
motor activity 1.9e-08 7 18.9 37 40 4566
myosin 1.0e-07 5 13.5 37 16 4566
cytoskeletal protein binding 3.6e-07 8 21.6 37 89 4566
cytoskeleton 5.2e-07 12 32.4 37 263 4566
actomyosin 2.4e-06 4 10.8 37 13 4566
actin binding 2.6e-06 7 18.9 37 80 4566
calmodulin binding 2.5e-05 5 13.5 37 45 4566
muscle myosin 5.6e-05 3 8.1 37 10 4566


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Visual display
Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.
You can also view the images within GeneXPress by loading the module gxp file file.
 
 





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