Module 533

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General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets: 5
Num genes: 45 (see 572 additional genes for this module)
Num experiments: 315 (47 induced, 268 repressed)
Parent module: None
Children modules: 438


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
Pollack99 13
Armstrong01 47
kinesin complex
microtubule cytoskeleton
microtubule associated complex


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Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation Category P-value Hits Hits(%) Module hits in category Arrays in annotation Arrays
Lung tissue, cancer or cell line (Lung cancer*) Lung cancer* 8.5e-108 176 65.9 267 276 1945
Cancer and cell line (Lung cancer*) Lung cancer* 1.4e-94 160 59.9 267 252 1945
Cancer (Lung cancer*) Lung cancer* 1.4e-94 160 59.9 267 252 1945
Lung cancer (Lung cancer*) Lung cancer* 1.1e-83 148 55.4 267 238 1945
Lung cancer or cell line (Lung cancer*) Lung cancer* 1.1e-83 148 55.4 267 238 1945
Non small cell lung cancer and cell line (Lung cancer*) Lung cancer* 5.8e-81 136 50.9 267 205 1945
Non small cell lung cancer (Lung cancer*) Lung cancer* 5.8e-81 136 50.9 267 205 1945
Cancer and cell line (Gliomas*) Gliomas* 9.9e-22 35 13.1 267 47 1945
Cancer (Gliomas*) Gliomas* 9.9e-22 35 13.1 267 47 1945
CNS cancer or cell line (Gliomas*) Gliomas* 9.9e-22 35 13.1 267 47 1945
CNS tissue, cancer or cell line (Gliomas*) Gliomas* 9.9e-22 35 13.1 267 47 1945
CNS tumor (Gliomas*) Gliomas* 9.9e-22 35 13.1 267 47 1945
Liver cancer cell line (Liver cancer) Liver cancer 5.7e-05 5 41.6 12 10 207
Cell line (Liver cancer) Liver cancer 0.0001 5 41.6 12 11 207
Adenocarcinoma (Lung cancer) Lung cancer 0.0002 120 68.1 176 166 276


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation P-value Hits Hits(%) Module genes Genes in annotation Genes
microtubule cytoskeleton 5.5e-46 35 87.5 40 176 4566
microtubule associated complex 2.2e-42 33 82.5 40 167 4566
cytoskeleton 1.6e-41 36 90 40 263 4566
kinesin complex 1.1e-39 31 77.5 40 151 4566
cytoskeleton-dependent intracellular transport 4.1e-07 6 15 40 35 4566
intracellular transport 6.8e-07 6 15 40 38 4566
structural constituent of cytoskeleton 7.9e-07 7 17.5 40 62 4566
nuclear lamina 1.2e-05 5 12.5 40 36 4566
intermediate filament 1.6e-05 5 12.5 40 38 4566
motor activity 2.0e-05 5 12.5 40 40 4566
nuclear membrane 3.7e-05 5 12.5 40 45 4566
microtubule-based movement 9.7e-05 3 7.5 40 11 4566


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Visual display
Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.
You can also view the images within GeneXPress by loading the module gxp file file.
 
 





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