Module 63 -- Porins/transporters

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General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets: 2
Num genes: 212 (see 2773 additional genes for this module)
Num experiments: 596 (216 induced, 380 repressed)
Parent module: None
Children modules: None


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
porin activity
channel/pore class transporter activity


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation Category P-value Hits Hits(%) Module hits in category Arrays in annotation Arrays
Liver tissue (Liver cancer*) Liver cancer* 7.4e-26 72 33.3 216 187 1945
Acute leukemia (Leukemia*) Leukemia* 1.1e-24 80 21.1 379 141 1945
Cancer and cell line (Leukemia*) Leukemia* 1.1e-24 80 21.1 379 141 1945
Cancer (Leukemia*) Leukemia* 1.1e-24 80 21.1 379 141 1945
Hematologic cancer and cell line (Leukemia*) Leukemia* 1.1e-24 80 21.1 379 141 1945
Hematologic cancer (Leukemia*) Leukemia* 1.1e-24 80 21.1 379 141 1945
Hematologic samples and cell lines (Leukemia*) Leukemia* 1.1e-24 80 21.1 379 141 1945
Leukemia (Leukemia*) Leukemia* 1.1e-24 80 21.1 379 141 1945
Leukemia or leukemia cell line (Leukemia*) Leukemia* 1.1e-24 80 21.1 379 141 1945
Monocytes (Leukemia*) Leukemia* 1.1e-24 80 21.1 379 141 1945
Liver tissue, cancer or cell line (Liver cancer*) Liver cancer* 3.4e-24 72 33.3 216 197 1945
Non-tumor liver tissue (Liver cancer) Liver cancer 4.2e-20 57 78.0 73 76 207
Hepatitis infected liver (Liver cancer*) Liver cancer* 2.6e-17 55 25.4 216 156 1945
Cancer and cell line (Liver cancer) Liver cancer 4.1e-17 65 98.4 66 126 207
Cancer (Liver cancer) Liver cancer 1.5e-08 55 83.3 66 115 207
Adenocarcinoma (Liver cancer) Liver cancer 5.2e-08 49 74.2 66 97 207
Breast tissue or cancer (Breast cancer*) Breast cancer* 1.3e-07 33 15.2 216 118 1945
Female hormonal tissue or cancer (Breast cancer*) Breast cancer* 1.3e-07 33 15.2 216 118 1945
Cell line (Breast cancer) Breast cancer 1.7e-07 20 50 40 30 152
B cells (Leukemia) Leukemia 2.6e-07 50 62.5 80 62 141
Breast cancer cell line (Breast cancer) Breast cancer 4.0e-07 14 35 40 17 152
Bone marrow (Leukemia) Leukemia 4.3e-07 23 28.7 80 23 141
Cell line (B lymphoma) B lymphoma 8.1e-07 11 23.9 46 14 245
Adenocarcinoma (Breast cancer*) Breast cancer* 1.4e-06 30 13.8 216 112 1945
Breast cancer (Breast cancer*) Breast cancer* 1.4e-06 30 13.8 216 112 1945
Cancer (Breast cancer*) Breast cancer* 1.4e-06 30 13.8 216 112 1945
Female hormonal cancer (Breast cancer*) Breast cancer* 1.4e-06 30 13.8 216 112 1945
Atypical teratoid/rhabdoid tumour - CNS and other origin (Neuro tumors) Neuro tumors 4.6e-06 7 63.6 11 10 90
Liver cancer cell line (Liver cancer) Liver cancer 6.6e-06 10 15.1 66 10 207
Female hormonal cancer cell line (Breast cancer) Breast cancer 6.7e-06 12 30 40 15 152
Hepatocellular carcinoma (Liver cancer) Liver cancer 7.4e-06 48 72.7 66 104 207
Activated B like DLBCL (B lymphoma) B lymphoma 7.5e-06 11 47.8 23 30 245
Female hormonal tissue, cancer or cell line (Breast cancer*) Breast cancer* 1.1e-05 33 15.2 216 141 1945
Breast tissue, cancer or cell line (Breast cancer*) Breast cancer* 1.2e-05 33 15.2 216 142 1945
Female hormonal cancer or cell line (Breast cancer*) Breast cancer* 2.4e-05 30 13.8 216 127 1945
Breast cancer or cell line (Breast cancer*) Breast cancer* 2.8e-05 30 13.8 216 128 1945
Primary blood mononuclear cells (Leukemia) Leukemia 4.0e-05 20 25 80 21 141
Cell line (Liver cancer) Liver cancer 5.3e-05 10 15.1 66 11 207
Lung carcinoid (Lung cancer) Lung cancer 0.0001 12 20.3 59 20 276
Liver tissue, cancer or cell line (Liver cancer*) Liver cancer* 0.0001 59 15.5 379 197 1945
Invasive liver tumor (Liver cancer) Liver cancer 0.0002 22 33.3 66 38 207
Cancer and cell line (Breast cancer*) Breast cancer* 0.0002 30 13.8 216 143 1945


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation P-value Hits Hits(%) Module genes Genes in annotation Genes
channel/pore class transporter activity 9.8e-271 212 100 212 351 4566
porin activity 3.4e-156 145 68.3 212 235 4566
receptor activity 9.5e-113 165 77.8 212 582 4566
integral to plasma membrane 1.0e-71 137 64.6 212 612 4566
alpha-type channel activity 1.0e-67 74 34.9 212 133 4566
transmembrane receptor activity 6.2e-63 114 53.7 212 448 4566
ion channel activity 1.6e-60 66 31.1 212 117 4566
transmembrane receptor protein kinase activity 3.7e-37 40 18.8 212 68 4566
ion transport 1.5e-36 60 28.3 212 188 4566
transmembrane receptor protein tyrosine kinase activity 2.8e-36 38 17.9 212 62 4566
signal transducer activity 1.8e-33 127 59.9 212 1026 4566
voltage-gated ion channel activity 4.5e-33 35 16.5 212 58 4566
ligand-gated ion channel activity 5.9e-26 28 13.2 212 48 4566
protein kinase activity 9.2e-26 38 17.9 212 102 4566
potassium ion transport 4.7e-22 24 11.3 212 42 4566
signal transduction 5.8e-22 98 46.2 212 831 4566
small molecule transport 1.3e-21 37 17.4 212 121 4566
extracellular ligand-gated ion channel activity 8.2e-21 21 9.9 212 33 4566
cell communication 9.5e-19 105 49.5 212 1030 4566
hematopoietin/interferon-class (D200-domain) cytokine receptor activity 8.6e-18 21 9.9 212 42 4566
potassium channel activity 6.4e-17 17 8.0 212 27 4566
voltage-gated potassium channel activity 2.6e-16 15 7.0 212 21 4566
cation transport 7.4e-16 31 14.6 212 120 4566
excitatory extracellular ligand-gated ion channel activity 1.3e-15 14 6.6 212 19 4566
protein tyrosine kinase activity 6.0e-15 30 14.1 212 120 4566
cell surface receptor linked signal transduction 7.7e-15 44 20.7 212 259 4566
transmembrane receptor protein tyrosine kinase signaling pathway 3.0e-14 20 9.4 212 52 4566
monovalent inorganic cation transport 3.3e-14 24 11.3 212 79 4566
synaptic transmission 1.3e-13 28 13.2 212 116 4566
eye photoreceptor cell fate commitment 1.3e-13 17 8.0 212 38 4566
compound eye morphogenesis (sensu Drosophila) 6.4e-13 17 8.0 212 41 4566
post-embryonic morphogenesis 6.4e-13 17 8.0 212 41 4566
post-embryonic development 1.0e-12 17 8.0 212 42 4566
voltage-gated potassium channel complex 1.0e-12 12 5.6 212 18 4566
vesicle-mediated transport 3.7e-11 33 15.5 212 196 4566
neurotransmitter receptor activity 1.9e-10 11 5.1 212 20 4566
chloride transport 2.2e-10 12 5.6 212 25 4566
GABA-A receptor activity 5.5e-10 10 4.7 212 17 4566
Fc receptor activity 7.8e-10 8 3.7 212 10 4566
nicotinic acetylcholine-activated cation-selective channel activity 7.8e-10 8 3.7 212 10 4566
response to extracellular stimulus 8.1e-10 54 25.4 212 500 4566
interleukin receptor activity 1.1e-09 12 5.6 212 28 4566
membrane fraction 2.4e-09 39 18.3 212 304 4566
integrin complex 4.6e-09 10 4.7 212 20 4566
inorganic anion transport 4.7e-09 12 5.6 212 31 4566
response to stress 1.0e-08 70 33.0 212 792 4566
acetylcholine receptor activity 1.4e-08 7 3.3 212 9 4566
nicotinic acetylcholine-gated receptor-channel complex 1.4e-08 7 3.3 212 9 4566
integrin-mediated signaling pathway 2.5e-08 10 4.7 212 23 4566
anion transport 3.4e-08 12 5.6 212 36 4566
cell adhesion receptor activity 4.1e-08 10 4.7 212 24 4566
immunoglobulin receptor activity 6.6e-08 10 4.7 212 25 4566
interleukin binding 6.6e-08 10 4.7 212 25 4566
immune response 1.4e-07 47 22.1 212 469 4566
actin filament-based movement 1.7e-07 12 5.6 212 41 4566
cell-matrix adhesion 3.4e-07 10 4.7 212 29 4566
protein amino acid phosphorylation 5.2e-07 29 13.6 212 230 4566
transmembrane receptor protein phosphatase activity 5.7e-07 7 3.3 212 13 4566
actin filament-based process 9.1e-07 12 5.6 212 47 4566
response to biotic stimulus 1.2e-06 53 25 212 600 4566
ephrin receptor activity 3.5e-06 6 2.8 212 11 4566
gap junction 4.0e-06 5 2.3 212 7 4566
gap-junction forming channel activity 4.0e-06 5 2.3 212 7 4566
delayed rectifier potassium channel activity 4.5e-06 4 1.8 212 4 4566
amine receptor activity 5.1e-06 9 4.2 212 30 4566
excretion 5.1e-06 9 4.2 212 30 4566
muscle contraction 7.4e-06 14 6.6 212 76 4566
NGF/TNF (6 C-domain) receptor activity 2.1e-05 4 1.8 212 5 4566
GPI-anchored membrane-bound receptor 2.2e-05 5 2.3 212 9 4566
inward rectifier potassium channel activity 2.2e-05 5 2.3 212 9 4566
voltage-gated chloride channel activity 2.2e-05 5 2.3 212 9 4566
calcium channel activity 6.2e-05 4 1.8 212 6 4566
defense/immunity protein activity 6.5e-05 15 7.0 212 103 4566
G-protein coupled receptor activity 9.4e-05 20 9.4 212 170 4566
rhodopsin-like receptor activity 0.0001 18 8.4 212 147 4566
two-component signal transduction system (phosphorelay) 0.0001 7 3.3 212 26 4566


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Visual display
Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.
You can also view the images within GeneXPress by loading the module gxp file file.
Note: Since there are 596 experiments, this image does not display the individual experiment names, but rather condenses each experiment to a single pixel without displaying its name. You can fully view the image for this module within GeneXPress, by loading any of the four files mentioned in the line above
 
 





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