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Daphne Koller Publications

Discovering Molecular Pathways from Protein Interaction and Gene Expression data (2003)

by E. Segal, H. Wang, and D. Koller


Abstract: In this paper, we describe an approach for identifying pathways from gene expression and protein interaction data. Our approach is based on the assumption that many pathways exhibit two properties: their genes exhibit a similar gene expression profile, and the protein products of the genes often interact. Our approach is based on a unified probabilistic model, which is learned from the data using the EM algorithm. We present results on two Saccharomyces cerevisiae gene expression data sets, combined with a binary protein interaction data set. Our results show that our approach is much more successful than other approaches at discovering both coherent functional groups and entire protein complexes.

Download Information

E. Segal, H. Wang, and D. Koller (2003). "Discovering Molecular Pathways from Protein Interaction and Gene Expression data." Bioinformatics, 19(S1 (Proc ISMB)). Winner of the ISMB Best Student Paper Award. pdf ps.gz

Bibtex citation

@article{Segal+al:ISMB03b,
  title = {Discovering Molecular Pathways from Protein Interaction and Gene Expression data},
  author = {E. Segal and H. Wang and D. Koller},
  journal = {Bioinformatics},
  volume = {19},
  number = {S1 (Proc ISMB)},
  Note = {Winner of the ISMB Best Student Paper Award},
  year = 2003,
}

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