Module 149 -- Translation factors

General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets:	7
Num genes:	37 (see 1222 additional genes for this module)
Num experiments:	114 (42 induced, 72 repressed)
Parent module:	None
Children modules:	115

Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
Translation Factors
translation initiation factor activity
translational initiation
regulation of translational initiation
eukaryotic 43S pre_initiation complex
Protein_export
ubiquinol_cytochrome c reductase activity

Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation	Category	P-value	Hits	Hits(%)	Module hits in category	Arrays in annotation	Arrays
Prostate (Prostate cancer*)	Prostate cancer*	2.8e-34	39	54.1	72	101	1945
Prostate (Prostate cancer*)	Prostate cancer*	6.7e-08	13	30.9	42	101	1945
Atypical teratoid/rhabdoid tumour - CNS and other origin (Neuro tumors)	Neuro tumors	0.0003	4	80	5	10	90

Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation	P-value	Hits	Hits(%)	Module genes	Genes in annotation	Genes
translation initiation factor activity	2.5e-30	17	48.5	35	31	4566
translation factor activity\, nucleic acid binding	1.6e-29	24	68.5	35	139	4566
regulation of translational initiation	2.9e-29	15	42.8	35	21	4566
translational initiation	7.0e-29	16	45.7	35	28	4566
protein biosynthesis	1.3e-28	24	68.5	35	151	4566
translation regulator activity	3.8e-27	24	68.5	35	172	4566
nucleic acid binding	2.5e-21	27	77.1	35	444	4566
eukaryotic translation initiation factor 3 complex	9.0e-13	6	17.1	35	7	4566
eukaryotic 43S pre-initiation complex	1.0e-11	6	17.1	35	9	4566
translational elongation	1.5e-11	7	20	35	17	4566
ubiquinol-cytochrome c reductase activity	1.9e-11	5	14.2	35	5	4566
eukaryotic translation initiation factor 4 complex	4.0e-10	5	14.2	35	7	4566
translation elongation factor activity	6.1e-10	6	17.1	35	15	4566
mitochondrial electron transport chain	2.4e-09	5	14.2	35	9	4566
inner membrane	2.0e-06	5	14.2	35	29	4566
ammonia oxidation	4.0e-06	3	8.5	35	5	4566
signal recognition particle	4.0e-06	3	8.5	35	5	4566
RNA binding	1.0e-05	10	28.5	35	249	4566
mitochondrial inner membrane	1.2e-05	5	14.2	35	41	4566
cation transporter activity	1.9e-05	5	14.2	35	45	4566
hydrogen ion transporter activity	3.2e-05	5	14.2	35	50	4566
mitochondrial membrane	4.7e-05	5	14.2	35	54	4566

Visual display

Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.

You can also view the images within GeneXPress by loading the module gxp file file.

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