Module 157

General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets:	16
Num genes:	108 (see 930 additional genes for this module)
Num experiments:	393 (115 induced, 278 repressed)
Parent module:	242
Children modules:	111

Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
Shipp02 41
Pomeroy02 49
Shipp02 42
Ramaswamy01 18
Golub99 31
Shipp02 20
Pomeroy02 10
Golub99 11
Shipp02 47
Ramaswamy01 6
Golub99 18
Ramaswamy01 8
Pomeroy02 13
Golub99 48
Golub99 44
Pomeroy02 40

Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation	Category	P-value	Hits	Hits(%)	Module hits in category	Arrays in annotation	Arrays
Prostate (Prostate cancer*)	Prostate cancer*	9.1e-30	62	22.3	278	101	1945
Cancer and cell line (Neuro tumors*)	Neuro tumors*	6.0e-16	43	15.4	278	86	1945
Cancer (Neuro tumors*)	Neuro tumors*	6.0e-16	43	15.4	278	86	1945
CNS cancer or cell line (Neuro tumors*)	Neuro tumors*	5.0e-13	38	13.6	278	81	1945
CNS tumor (Neuro tumors*)	Neuro tumors*	5.0e-13	38	13.6	278	81	1945
CNS tissue, cancer or cell line (Neuro tumors*)	Neuro tumors*	3.3e-12	38	13.6	278	85	1945
Prostate (Prostate cancer*)	Prostate cancer*	1.3e-07	21	18.2	115	101	1945
Cell line (Breast cancer)	Breast cancer	4.6e-07	12	75	16	30	152
Breast cancer cell line (Breast cancer)	Breast cancer	3.3e-05	8	50	16	17	152
Non-tumor liver tissue (Liver cancer)	Liver cancer	4.2e-05	16	80	20	76	207
Cancer and cell line (Gliomas*)	Gliomas*	0.0001	17	6.1	278	47	1945
Cancer (Gliomas*)	Gliomas*	0.0001	17	6.1	278	47	1945
CNS cancer or cell line (Gliomas*)	Gliomas*	0.0001	17	6.1	278	47	1945
CNS tissue, cancer or cell line (Gliomas*)	Gliomas*	0.0001	17	6.1	278	47	1945
CNS tumor (Gliomas*)	Gliomas*	0.0001	17	6.1	278	47	1945
Female hormonal cancer cell line (Breast cancer)	Breast cancer	0.0001	7	43.7	16	15	152
CNS tissue, cancer or cell line (Neuro tumors*)	Neuro tumors*	0.0003	14	12.1	115	85	1945
Breast tissue or cancer (NCI60)	NCI60	0.0003	3	42.8	7	4	139
Female hormonal tissue or cancer (NCI60)	NCI60	0.0003	3	42.8	7	4	139
Atypical teratoid/rhabdoid tumour - CNS and other origin (Neuro tumors)	Neuro tumors	0.0003	10	23.2	43	10	90

Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).

Visual display

Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.

You can also view the images within GeneXPress by loading the module gxp file file.

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