Module 188

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General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets: 3
Num genes: 142 (see 1261 additional genes for this module)
Num experiments: 357 (136 induced, 221 repressed)
Parent module: 238
Children modules: 145


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
Rosenwald01 31
Rosenwald01 9
Alizadeh00 18


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation Category P-value Hits Hits(%) Module hits in category Arrays in annotation Arrays
Lymphocytes (B lymphoma*) B lymphoma* 2.6e-36 75 55.1 136 244 1945
B cells (B lymphoma*) B lymphoma* 4.8e-36 73 53.6 136 231 1945
Hematologic cancer and cell line (Stimulated PBMC) Stimulated PBMC 1.0e-28 30 83.3 36 30 182
Macrophages (Stimulated PBMC) Stimulated PBMC 1.0e-28 30 83.3 36 30 182
Cancer (B lymphoma*) B lymphoma* 4.5e-28 61 44.8 136 200 1945
Hematologic cancer (B lymphoma*) B lymphoma* 4.5e-28 61 44.8 136 200 1945
Chronic lymphocytic leukemia (B lymphoma) B lymphoma 8.4e-28 45 60 75 46 245
Leukemia (B lymphoma) B lymphoma 8.4e-28 45 60 75 46 245
Leukemia or leukemia cell line (B lymphoma) B lymphoma 8.4e-28 45 60 75 46 245
Cancer and cell line (B lymphoma*) B lymphoma* 3.2e-26 61 44.8 136 214 1945
Hematologic cancer and cell line (B lymphoma*) B lymphoma* 3.2e-26 61 44.8 136 214 1945
Lymphocytes (B lymphoma*) B lymphoma* 5.6e-22 79 35.7 221 244 1945
Cancer and cell line (B lymphoma*) B lymphoma* 1.0e-21 73 33.0 221 214 1945
Hematologic cancer and cell line (B lymphoma*) B lymphoma* 1.0e-21 73 33.0 221 214 1945
B cells (B lymphoma*) B lymphoma* 9.7e-17 69 31.2 221 231 1945
Cancer (B lymphoma*) B lymphoma* 6.6e-14 59 26.6 221 200 1945
Hematologic cancer (B lymphoma*) B lymphoma* 6.6e-14 59 26.6 221 200 1945
Diffuse large B cell lymphoma tumor or cell line (B lymphoma) B lymphoma 5.8e-11 67 83.7 80 134 245
Cell line (B lymphoma) B lymphoma 6.8e-08 14 17.5 80 14 245
Lymphoma or lymphoma cell line (B lymphoma) B lymphoma 7.3e-08 72 90 80 167 245
Diffuse large B cell lymphoma - DLBCL (B lymphoma) B lymphoma 7.9e-07 59 73.7 80 126 245
Female hormonal cancer cell line (Breast cancer) Breast cancer 1.8e-06 9 50 18 15 152
Cell line (Breast cancer) Breast cancer 3.6e-06 12 66.6 18 30 152
Breast cancer cell line (Breast cancer) Breast cancer 7.8e-06 9 50 18 17 152
Breast cancer (NCI60) NCI60 4.5e-05 3 50 6 3 139
CNS tissue, cancer or cell line (Various tumors) Various tumors 7.5e-05 11 40.7 27 21 154
Medulloblastoma (Various tumors) Various tumors 0.0001 6 22.2 27 7 154
Liver cancer cell line (Liver cancer) Liver cancer 0.0001 5 35.7 14 10 207
GC B like DLBCL (B lymphoma) B lymphoma 0.0001 29 36.2 80 53 245
B. petrussis 537 stimulated immune cells (Stimulated PBMC) Stimulated PBMC 0.0001 5 18.5 27 5 144
B. petrussis A2 stimulated immune cells (Stimulated PBMC) Stimulated PBMC 0.0001 5 18.5 27 5 144
B. petrussis Tox 6 stimulated immune cells (Stimulated PBMC) Stimulated PBMC 0.0001 5 18.5 27 5 144
Breast tissue or cancer (NCI60) NCI60 0.0001 3 50 6 4 139
Female hormonal tissue or cancer (NCI60) NCI60 0.0001 3 50 6 4 139
CNS cancer or cell line (Various tumors) Various tumors 0.0002 9 33.3 27 16 154
CNS tumor (Various tumors) Various tumors 0.0002 9 33.3 27 16 154
Activated B like DLBCL (B lymphoma) B lymphoma 0.0002 19 23.7 80 30 245
Cell line (Liver cancer) Liver cancer 0.0002 5 35.7 14 11 207
B. petrussis stimulated immune cells (Stimulated PBMC) Stimulated PBMC 0.0002 21 77.7 27 67 144
Acute myelogeous leukemia (Leukemia) Leukemia 0.0003 15 71.4 21 50 141
Hematologic samples and cell lines (Stimulated PBMC*) Stimulated PBMC* 0.0003 36 16.2 221 182 1945
Monocytes (Stimulated PBMC*) Stimulated PBMC* 0.0003 36 16.2 221 182 1945


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation P-value Hits Hits(%) Module genes Genes in annotation Genes
interleukin binding 8.9e-05 4 8.8 45 25 4566


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Visual display
Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.
You can also view the images within GeneXPress by loading the module gxp file file.
 
 





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