Module 2 -- DRG (dorsal root ganglia) genes

General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets:	2
Num genes:	384 (see 3102 additional genes for this module)
Num experiments:	1318 (374 induced, 944 repressed)
Parent module:	None
Children modules:	None

Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
DRG_2
DRG_1

Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation	Category	P-value	Hits	Hits(%)	Module hits in category	Arrays in annotation	Arrays
Liver tissue (Liver cancer*)	Liver cancer*	7.4e-26	96	25.7	373	187	1945
Cancer and cell line (Lung cancer*)	Lung cancer*	4.7e-25	197	20.8	943	252	1945
Cancer (Lung cancer*)	Lung cancer*	4.7e-25	197	20.8	943	252	1945
Liver tissue, cancer or cell line (Liver cancer*)	Liver cancer*	1.3e-23	96	25.7	373	197	1945
Lung cancer (Lung cancer*)	Lung cancer*	2.9e-22	184	19.5	943	238	1945
Lung cancer or cell line (Lung cancer*)	Lung cancer*	2.9e-22	184	19.5	943	238	1945
Hepatitis infected liver (Liver cancer*)	Liver cancer*	1.7e-18	76	20.3	373	156	1945
CNS tissue, cancer or cell line (Neuro tumors*)	Neuro tumors*	3.6e-18	78	8.2	943	85	1945
Non small cell lung cancer and cell line (Lung cancer*)	Lung cancer*	3.7e-18	157	16.6	943	205	1945
Non small cell lung cancer (Lung cancer*)	Lung cancer*	3.7e-18	157	16.6	943	205	1945
CNS cancer or cell line (Neuro tumors*)	Neuro tumors*	4.4e-18	75	7.9	943	81	1945
CNS tumor (Neuro tumors*)	Neuro tumors*	4.4e-18	75	7.9	943	81	1945
Lung tissue, cancer or cell line (Lung cancer*)	Lung cancer*	8.2e-18	199	21.1	943	276	1945
Cancer and cell line (Neuro tumors*)	Neuro tumors*	2.1e-17	78	8.2	943	86	1945
Cancer (Neuro tumors*)	Neuro tumors*	2.1e-17	78	8.2	943	86	1945
Non-tumor liver tissue (Liver cancer)	Liver cancer	4.5e-17	64	65.9	97	76	207
Cancer and cell line (Liver cancer)	Liver cancer	2.0e-15	70	94.5	74	126	207
Cancer and cell line (Various tumors*)	Various tumors*	3.8e-11	83	8.8	943	105	1945
Cancer (Various tumors*)	Various tumors*	3.8e-11	83	8.8	943	105	1945
Acute leukemia (Leukemia*)	Leukemia*	6.8e-10	103	10.9	943	141	1945
Cancer and cell line (Leukemia*)	Leukemia*	6.8e-10	103	10.9	943	141	1945
Cancer (Leukemia*)	Leukemia*	6.8e-10	103	10.9	943	141	1945
Hematologic cancer and cell line (Leukemia*)	Leukemia*	6.8e-10	103	10.9	943	141	1945
Hematologic cancer (Leukemia*)	Leukemia*	6.8e-10	103	10.9	943	141	1945
Hematologic samples and cell lines (Leukemia*)	Leukemia*	6.8e-10	103	10.9	943	141	1945
Leukemia (Leukemia*)	Leukemia*	6.8e-10	103	10.9	943	141	1945
Leukemia or leukemia cell line (Leukemia*)	Leukemia*	6.8e-10	103	10.9	943	141	1945
Monocytes (Leukemia*)	Leukemia*	6.8e-10	103	10.9	943	141	1945
Hematologic samples and cell lines (Various tumors)	Various tumors	3.8e-09	37	37.3	99	37	154
Hematologic samples (Various tumors)	Various tumors	3.8e-09	37	37.3	99	37	154
Cancer (Liver cancer)	Liver cancer	1.7e-08	60	81.0	74	115	207
Cancer and cell line (Various tumors)	Various tumors	3.5e-08	83	83.8	99	105	154
Cancer (Various tumors)	Various tumors	3.5e-08	83	83.8	99	105	154
Hematologic cancer and cell line (Various tumors)	Various tumors	1.4e-07	31	31.3	99	31	154
Hematologic cancer (Various tumors)	Various tumors	1.4e-07	31	31.3	99	31	154
Primary blood mononuclear cells (Various tumors)	Various tumors	1.4e-07	31	31.3	99	31	154
Lymphocytes (Various tumors)	Various tumors	8.4e-07	28	28.2	99	28	154
Monocytes (Various tumors)	Various tumors	8.4e-07	28	28.2	99	28	154
Activated B like DLBCL (B lymphoma)	B lymphoma	9.7e-07	16	38.0	42	30	245
Diffuse large B cell lymphoma - DLBCL (B lymphoma)	B lymphoma	2.9e-06	35	83.3	42	126	245
Cell line (NCI60*)	NCI60*	3.3e-06	91	9.6	943	135	1945
Epithelial cell line (NCI60)	NCI60	4.8e-06	31	33.6	92	32	139
Breast tissue or cancer (Breast cancer*)	Breast cancer*	1.0e-05	42	11.2	373	118	1945
Female hormonal tissue or cancer (Breast cancer*)	Breast cancer*	1.0e-05	42	11.2	373	118	1945
Acute lymphocytic leukemia (Leukemia)	Leukemia	1.3e-05	85	76.5	111	99	149
B cells (Various tumors)	Various tumors	1.3e-05	23	23.2	99	23	154
Cancer and cell line (NCI60*)	NCI60*	1.3e-05	91	9.6	943	138	1945
Cancer and cell line (Gliomas*)	Gliomas*	1.6e-05	37	3.9	943	47	1945
Cancer (Gliomas*)	Gliomas*	1.6e-05	37	3.9	943	47	1945
CNS cancer or cell line (Gliomas*)	Gliomas*	1.6e-05	37	3.9	943	47	1945
CNS tissue, cancer or cell line (Gliomas*)	Gliomas*	1.6e-05	37	3.9	943	47	1945
CNS tumor (Gliomas*)	Gliomas*	1.6e-05	37	3.9	943	47	1945
Liver cancer cell line (Liver cancer)	Liver cancer	2.2e-05	10	13.5	74	10	207
Diffuse large B cell lymphoma tumor or cell line (B lymphoma)	B lymphoma	2.2e-05	35	83.3	42	134	245
B cells (Leukemia)	Leukemia	2.5e-05	56	54.3	103	62	141
Adenocarcinoma (Liver cancer)	Liver cancer	2.6e-05	49	66.2	74	97	207
Lymphocytes (Leukemia)	Leukemia	4.3e-05	77	74.7	103	91	141
Hepatocellular carcinoma (Liver cancer)	Liver cancer	4.8e-05	51	68.9	74	104	207
Breast cancer cell line (Breast cancer)	Breast cancer	5.1e-05	14	25.4	55	17	152
Normal female hormonal tissue and cells (Various tumors)	Various tumors	5.8e-05	5	41.6	12	8	154
Normal female hormonal tissue (Various tumors)	Various tumors	5.8e-05	5	41.6	12	8	154
Lymphoma (Various tumors)	Various tumors	6.7e-05	20	20.2	99	20	154
Cell line (Breast cancer)	Breast cancer	0.0001	20	36.3	55	30	152
Stage T2 (Lung cancer)	Lung cancer	0.0001	10	55.5	18	35	195
Cell line (Liver cancer)	Liver cancer	0.0001	10	13.5	74	11	207
Normal tissue (Various tumors)	Various tumors	0.0002	10	83.3	12	49	154
Adenocarcinoma (Breast cancer*)	Breast cancer*	0.0002	37	9.9	373	112	1945
Breast cancer (Breast cancer*)	Breast cancer*	0.0002	37	9.9	373	112	1945
Cancer (Breast cancer*)	Breast cancer*	0.0002	37	9.9	373	112	1945
Female hormonal cancer (Breast cancer*)	Breast cancer*	0.0002	37	9.9	373	112	1945
Female hormonal cancer cell line (Breast cancer)	Breast cancer	0.0003	12	21.8	55	15	152

Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation	P-value	Hits	Hits(%)	Module genes	Genes in annotation	Genes
extracellular matrix structural constituent	1.3e-05	23	8.6	267	149	4566
cell adhesion molecule activity	2.5e-05	19	7.1	267	114	4566
cell adhesion	2.7e-05	29	10.8	267	222	4566
coated pit	0.0001	6	2.2	267	15	4566

Visual display

Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.

You can also view the images within GeneXPress by loading the module gxp file file.

Note: Since there are 1318 experiments, this image does not display the individual experiment names, but rather condenses each experiment to a single pixel without displaying its name. You can fully view the image for this module within GeneXPress, by loading any of the four files mentioned in the line above

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