Module 200

General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets:	5
Num genes:	27 (see 854 additional genes for this module)
Num experiments:	253 (80 induced, 173 repressed)
Parent module:	259
Children modules:	80

Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
transmembrane receptor protein tyrosine kinase signaling pathway
post_embryonic morphogenesis
post_embryonic development
eye photoreceptor cell fate commitment
compound eye morphogenesis (sensu Drosophila)

Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation	Category	P-value	Hits	Hits(%)	Module hits in category	Arrays in annotation	Arrays
Acute leukemia (Leukemia*)	Leukemia*	7.9e-10	36	20.8	173	141	1945
Cancer and cell line (Leukemia*)	Leukemia*	7.9e-10	36	20.8	173	141	1945
Cancer (Leukemia*)	Leukemia*	7.9e-10	36	20.8	173	141	1945
Hematologic cancer and cell line (Leukemia*)	Leukemia*	7.9e-10	36	20.8	173	141	1945
Hematologic cancer (Leukemia*)	Leukemia*	7.9e-10	36	20.8	173	141	1945
Hematologic samples and cell lines (Leukemia*)	Leukemia*	7.9e-10	36	20.8	173	141	1945
Leukemia (Leukemia*)	Leukemia*	7.9e-10	36	20.8	173	141	1945
Leukemia or leukemia cell line (Leukemia*)	Leukemia*	7.9e-10	36	20.8	173	141	1945
Monocytes (Leukemia*)	Leukemia*	7.9e-10	36	20.8	173	141	1945
Cell line (Breast cancer)	Breast cancer	1.3e-07	12	80	15	30	152
Liver tissue (Liver cancer*)	Liver cancer*	5.6e-07	23	28.7	80	187	1945
Cell line (NCI60*)	NCI60*	8.6e-07	19	23.7	80	135	1945
Breast cancer cell line (Breast cancer)	Breast cancer	9.4e-07	9	60	15	17	152
Cancer and cell line (NCI60*)	NCI60*	1.2e-06	19	23.7	80	138	1945
Liver tissue, cancer or cell line (Liver cancer*)	Liver cancer*	1.4e-06	23	28.7	80	197	1945
B cells (Leukemia)	Leukemia	2.2e-06	28	77.7	36	62	141
Cancer and cell line (Liver cancer)	Liver cancer	4.6e-06	23	100	23	126	207
Female hormonal cancer cell line (Breast cancer)	Breast cancer	5.1e-06	8	53.3	15	15	152
Cancer and cell line (Lung cancer*)	Lung cancer*	5.6e-06	43	24.8	173	252	1945
Cancer (Lung cancer*)	Lung cancer*	5.6e-06	43	24.8	173	252	1945
Lymphoma (B lymphoma)	B lymphoma	6.1e-06	10	100	10	77	245
Lung cancer (Lung cancer*)	Lung cancer*	7.8e-06	41	23.6	173	238	1945
Lung cancer or cell line (Lung cancer*)	Lung cancer*	7.8e-06	41	23.6	173	238	1945
Non-tumor liver tissue (Liver cancer)	Liver cancer	8.2e-06	19	79.1	24	76	207
Hematologic samples and cell lines (Various tumors)	Various tumors	1.0e-05	10	83.3	12	37	154
Hematologic samples (Various tumors)	Various tumors	1.0e-05	10	83.3	12	37	154
Acute lymphocytic leukemia (Leukemia)	Leukemia	2.3e-05	36	92.3	39	99	149
Lymphocytes (Leukemia)	Leukemia	3.0e-05	33	91.6	36	91	141
Hepatitis infected liver (Liver cancer*)	Liver cancer*	3.2e-05	18	22.5	80	156	1945
Lung tissue, cancer or cell line (Lung cancer*)	Lung cancer*	6.3e-05	43	24.8	173	276	1945
Bone marrow (Leukemia)	Leukemia	8.3e-05	14	38.8	36	23	141
Centroblasts (Various tumors)	Various tumors	0.0001	4	33.3	12	5	154
GC B like DLBCL (Various tumors)	Various tumors	0.0001	4	33.3	12	5	154
Cancer (Liver cancer)	Liver cancer	0.0001	21	91.3	23	115	207
Primary blood mononuclear cells (Leukemia)	Leukemia	0.0001	13	36.1	36	21	141
Large cell lung cancer (Lung cancer)	Lung cancer	0.0001	3	27.2	11	4	276
Adenocarcinoma (Liver cancer)	Liver cancer	0.0002	19	82.6	23	97	207
Epithelial cell line (Breast cancer)	Breast cancer	0.0003	7	46.6	15	18	152
Normal female hormonal tissue and cells (Various tumors)	Various tumors	0.0003	3	75	4	8	154
Normal female hormonal tissue (Various tumors)	Various tumors	0.0003	3	75	4	8	154

Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation	P-value	Hits	Hits(%)	Module genes	Genes in annotation	Genes
post-embryonic morphogenesis	6.4e-47	23	85.1	27	41	4566
transmembrane receptor protein tyrosine kinase signaling pathway	1.1e-46	24	88.8	27	52	4566
post-embryonic development	1.4e-46	23	85.1	27	42	4566
eye photoreceptor cell fate commitment	4.7e-39	20	74.0	27	38	4566
compound eye morphogenesis (sensu Drosophila)	3.7e-38	20	74.0	27	41	4566
morphogenesis	5.5e-26	25	92.5	27	366	4566
development	2.1e-21	25	92.5	27	554	4566
transmembrane receptor protein tyrosine kinase activity	2.6e-20	14	51.8	27	62	4566
transmembrane receptor protein kinase activity	1.1e-19	14	51.8	27	68	4566
protein kinase activity	4.8e-17	14	51.8	27	102	4566
signal transducer activity	3.1e-13	24	88.8	27	1026	4566
receptor activity	3.5e-13	20	74.0	27	582	4566
transmembrane receptor activity	1.0e-12	18	66.6	27	448	4566
protein amino acid phosphorylation	5.1e-12	14	51.8	27	230	4566
porin activity	1.3e-10	13	48.1	27	235	4566
response to DNA damage stimulus	2.9e-10	14	51.8	27	310	4566
ATP binding	8.4e-09	14	51.8	27	399	4566
protein tyrosine kinase activity	1.3e-08	9	33.3	27	120	4566
nucleotidyltransferase activity	1.9e-08	14	51.8	27	425	4566
channel/pore class transporter activity	1.9e-08	13	48.1	27	351	4566
response to stress	1.4e-07	17	62.9	27	792	4566
integral to plasma membrane	2.5e-07	15	55.5	27	612	4566
ephrin receptor activity	3.1e-07	4	14.8	27	11	4566
MHC protein binding	1.8e-06	3	11.1	27	5	4566
eye morphogenesis (sensu Drosophila)	3.6e-06	3	11.1	27	6	4566
signal transduction	1.3e-05	15	55.5	27	831	4566
enzyme linked receptor protein signaling pathway	1.5e-05	4	14.8	27	27	4566
coreceptor activity	2.1e-05	3	11.1	27	10	4566
cell surface receptor linked signal transduction	8.3e-05	8	29.6	27	259	4566

Visual display

Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.

You can also view the images within GeneXPress by loading the module gxp file file.

>4x