Module 372

General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets:	14
Num genes:	24 (see 307 additional genes for this module)
Num experiments:	131 (52 induced, 79 repressed)
Parent module:	441
Children modules:	None

Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
Detweiler01 19
Boldrick02 5
Ross01 43
Shipp02 16
Monoamine GPCRs
Iyer99 44
brain development
Ross01 10
transcription factor activity
Cuadras02 48
Garber01 48
cell cycle checkpoint
Staunton01 19
Perou00 49

Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation	Category	P-value	Hits	Hits(%)	Module hits in category	Arrays in annotation	Arrays
Liver tissue (Liver cancer*)	Liver cancer*	1.9e-11	29	36.7	79	187	1945
Hepatitis infected liver (Liver cancer*)	Liver cancer*	5.8e-11	26	32.9	79	156	1945
Liver tissue, cancer or cell line (Liver cancer*)	Liver cancer*	7.7e-11	29	36.7	79	197	1945
Non-tumor liver tissue (Liver cancer)	Liver cancer	4.6e-09	25	86.2	29	76	207
Small cell lung cancer (Lung cancer)	Lung cancer	1.5e-07	6	54.5	11	10	276
Lung tissue, cancer or cell line (Lung cancer*)	Lung cancer*	2.7e-07	29	36.7	79	276	1945
Liver tissue, cancer or cell line (Liver cancer*)	Liver cancer*	1.1e-06	18	34.6	52	197	1945
Hepatitis infected liver (Liver cancer*)	Liver cancer*	1.1e-06	16	30.7	52	156	1945
Non small cell lung cancer and cell line (Lung cancer*)	Lung cancer*	2.3e-06	23	29.1	79	205	1945
Non small cell lung cancer (Lung cancer*)	Lung cancer*	2.3e-06	23	29.1	79	205	1945
Liver tissue (Liver cancer*)	Liver cancer*	1.3e-05	16	30.7	52	187	1945
Cancer and cell line (Fibroblast EWS-FLI*)	Fibroblast EWS-FLI*	2.0e-05	5	6.3	79	10	1945
Cell line (Fibroblast EWS-FLI*)	Fibroblast EWS-FLI*	2.0e-05	5	6.3	79	10	1945
EWS/FLI expressing fibroblasts (Fibroblast EWS-FLI*)	Fibroblast EWS-FLI*	2.0e-05	5	6.3	79	10	1945
Fibroblasts (Fibroblast EWS-FLI*)	Fibroblast EWS-FLI*	2.0e-05	5	6.3	79	10	1945
Skin fibroblasts (Fibroblast EWS-FLI*)	Fibroblast EWS-FLI*	2.0e-05	5	6.3	79	10	1945
Lung cancer (Lung cancer*)	Lung cancer*	3.2e-05	23	29.1	79	238	1945
Lung cancer or cell line (Lung cancer*)	Lung cancer*	3.2e-05	23	29.1	79	238	1945
Cancer and cell line (Liver cancer)	Liver cancer	4.4e-05	19	100	19	126	207
Cancer and cell line (Lung cancer*)	Lung cancer*	8.1e-05	23	29.1	79	252	1945
Cancer (Lung cancer*)	Lung cancer*	8.1e-05	23	29.1	79	252	1945
Bone marrow (Leukemia)	Leukemia	0.0001	7	70	10	23	141

Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).

Visual display

Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.

You can also view the images within GeneXPress by loading the module gxp file file.

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