Module 373 -- Oxidoreductases

General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets:	5
Num genes:	22 (see 1215 additional genes for this module)
Num experiments:	356 (115 induced, 241 repressed)
Parent module:	None
Children modules:	287

Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
Tyrosine_metabolism
Histidine_metabolism
vision
perception of light
oxidoreductase activity, acting on the CH_NH2 group of donors

Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation	Category	P-value	Hits	Hits(%)	Module hits in category	Arrays in annotation	Arrays
Cancer and cell line (Lung cancer*)	Lung cancer*	1.5e-83	145	60.1	241	252	1945
Cancer (Lung cancer*)	Lung cancer*	1.5e-83	145	60.1	241	252	1945
Lung tissue, cancer or cell line (Lung cancer*)	Lung cancer*	2.2e-78	147	60.9	241	276	1945
Lung cancer (Lung cancer*)	Lung cancer*	1.6e-72	133	55.1	241	238	1945
Lung cancer or cell line (Lung cancer*)	Lung cancer*	1.6e-72	133	55.1	241	238	1945
Non small cell lung cancer and cell line (Lung cancer*)	Lung cancer*	4.2e-62	116	48.1	241	205	1945
Non small cell lung cancer (Lung cancer*)	Lung cancer*	4.2e-62	116	48.1	241	205	1945
Liver tissue (Liver cancer*)	Liver cancer*	8.1e-46	69	60.5	114	187	1945
Liver tissue, cancer or cell line (Liver cancer*)	Liver cancer*	5.3e-44	69	60.5	114	197	1945
Hepatitis infected liver (Liver cancer*)	Liver cancer*	2.9e-31	53	46.4	114	156	1945
Cancer and cell line (Liver cancer)	Liver cancer	1.2e-10	40	100	40	126	207
Hematologic samples and cell lines (Various tumors)	Various tumors	1.0e-08	21	65.6	32	37	154
Hematologic samples (Various tumors)	Various tumors	1.0e-08	21	65.6	32	37	154
Non-tumor liver tissue (Liver cancer)	Liver cancer	1.5e-08	44	63.7	69	76	207
Metastasis (Liver cancer)	Liver cancer	2.6e-08	10	25	40	10	207
Liver cancer cell line (Liver cancer)	Liver cancer	1.4e-06	9	22.5	40	10	207
Hematologic cancer and cell line (Various tumors)	Various tumors	1.7e-06	17	53.1	32	31	154
Hematologic cancer (Various tumors)	Various tumors	1.7e-06	17	53.1	32	31	154
Primary blood mononuclear cells (Various tumors)	Various tumors	1.7e-06	17	53.1	32	31	154
Cell line (Liver cancer)	Liver cancer	6.8e-06	9	22.5	40	11	207
Lymphocytes (Various tumors)	Various tumors	1.6e-05	15	46.8	32	28	154
Monocytes (Various tumors)	Various tumors	1.6e-05	15	46.8	32	28	154
Normal tissue (Various tumors)	Various tumors	4.4e-05	10	90.9	11	49	154
Cancer and cell line (Various tumors*)	Various tumors*	9.3e-05	27	11.2	241	105	1945
Cancer (Various tumors*)	Various tumors*	9.3e-05	27	11.2	241	105	1945
Colon cancer (Liver cancer)	Liver cancer	0.0002	5	12.5	40	5	207
Colon cancer metastasis to liver (Liver cancer)	Liver cancer	0.0002	5	12.5	40	5	207
Colon cancer or cell line (Liver cancer)	Liver cancer	0.0002	5	12.5	40	5	207
Colon tissue, cancer or cell line (Liver cancer)	Liver cancer	0.0002	5	12.5	40	5	207
B cells (Various tumors)	Various tumors	0.0002	12	37.5	32	23	154

Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation	P-value	Hits	Hits(%)	Module genes	Genes in annotation	Genes
oxidoreductase activity	2.1e-17	16	80	20	254	4566
electron transporter activity	2.9e-15	15	75	20	269	4566
alcohol metabolism	9.0e-12	6	30	20	14	4566
oxidoreductase activity\, acting on the aldehyde or oxo group of donors	3.7e-11	6	30	20	17	4566
aldehyde dehydrogenase activity	2.3e-10	5	25	20	10	4566
amine oxidase activity	1.3e-09	4	20	20	5	4566
oxidoreductase activity\, acting on the aldehyde or oxo group of donors\, NAD or NADP as acceptor	1.8e-09	5	25	20	14	4566
catalytic activity	1.8e-09	20	100	20	1677	4566
xenobiotic metabolism	6.6e-09	6	30	20	37	4566
oxidoreductase activity\, acting on the CH-NH2 group of donors\, oxygen as acceptor	1.8e-08	4	20	20	8	4566
oxidoreductase activity\, acting on the CH-NH2 group of donors	3.3e-08	4	20	20	9	4566
response to xenobiotic stimulus	3.9e-08	8	40	20	133	4566
alcohol dehydrogenase activity\, zinc-dependent	5.5e-08	4	20	20	10	4566
alcohol dehydrogenase activity	1.2e-07	4	20	20	12	4566
amine metabolism	1.4e-07	5	25	20	31	4566
response to chemical substance	1.7e-07	10	50	20	308	4566
carboxylic acid metabolism	1.1e-06	7	35	20	138	4566
organic acid metabolism	1.1e-06	7	35	20	139	4566
oxidoreductase activity\, acting on CH-OH group of donors	2.3e-06	5	25	20	53	4566
oxidoreductase activity\, acting on the CH-OH group of donors\, NAD or NADP as acceptor	2.3e-06	5	25	20	53	4566
transition metal ion binding	3.0e-06	7	35	20	160	4566
amino acid and derivative metabolism	3.7e-06	4	20	20	26	4566
aldehyde metabolism	8.4e-06	3	15	20	10	4566

Visual display

Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.

You can also view the images within GeneXPress by loading the module gxp file file.

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