Module 375 -- GPCR signaling pathways (immune and neuro)

General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets:	7
Num genes:	90 (see 1196 additional genes for this module)
Num experiments:	619 (191 induced, 428 repressed)
Parent module:	None
Children modules:	288 289

Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
G_protein chemoattractant receptor activity
Peptide GPCRs
cytosolic calcium ion concentration elevation
peptide receptor activity, G_protein coupled
peptide receptor activity
conjugation without cellular fusion
G_protein coupled receptor protein signaling pathway

Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation	Category	P-value	Hits	Hits(%)	Module hits in category	Arrays in annotation	Arrays
Cancer and cell line (Various tumors*)	Various tumors*	2.9e-22	68	15.8	428	105	1945
Cancer (Various tumors*)	Various tumors*	2.9e-22	68	15.8	428	105	1945
Liver tissue (Liver cancer*)	Liver cancer*	3.5e-21	62	32.4	191	187	1945
Liver tissue, cancer or cell line (Liver cancer*)	Liver cancer*	8.2e-20	62	32.4	191	197	1945
Hepatitis infected liver (Liver cancer*)	Liver cancer*	1.1e-17	52	27.2	191	156	1945
Hematologic cancer and cell line (Stimulated PBMC)	Stimulated PBMC	7.2e-14	21	70	30	30	182
Macrophages (Stimulated PBMC)	Stimulated PBMC	7.2e-14	21	70	30	30	182
Cancer and cell line (Liver cancer)	Liver cancer	4.3e-12	45	100	45	126	207
Lymphoma (B lymphoma)	B lymphoma	1.3e-11	44	64.7	68	77	245
Acute leukemia (Leukemia*)	Leukemia*	1.0e-10	64	14.9	428	141	1945
Cancer and cell line (Leukemia*)	Leukemia*	1.0e-10	64	14.9	428	141	1945
Cancer (Leukemia*)	Leukemia*	1.0e-10	64	14.9	428	141	1945
Hematologic cancer and cell line (Leukemia*)	Leukemia*	1.0e-10	64	14.9	428	141	1945
Hematologic cancer (Leukemia*)	Leukemia*	1.0e-10	64	14.9	428	141	1945
Hematologic samples and cell lines (Leukemia*)	Leukemia*	1.0e-10	64	14.9	428	141	1945
Leukemia (Leukemia*)	Leukemia*	1.0e-10	64	14.9	428	141	1945
Leukemia or leukemia cell line (Leukemia*)	Leukemia*	1.0e-10	64	14.9	428	141	1945
Monocytes (Leukemia*)	Leukemia*	1.0e-10	64	14.9	428	141	1945
Acute lymphocytic leukemia (Leukemia)	Leukemia	1.6e-10	65	91.5	71	99	149
Non-tumor liver tissue (Liver cancer)	Liver cancer	3.1e-10	43	69.3	62	76	207
Hematologic samples and cell lines (B lymphoma)	B lymphoma	4.6e-10	55	80.8	68	121	245
Lymphocytes (Leukemia)	Leukemia	1.1e-09	58	90.6	64	91	141
Adenocarcinoma (Liver cancer)	Liver cancer	5.9e-09	38	84.4	45	97	207
Cancer (Liver cancer)	Liver cancer	1.0e-08	41	91.1	45	115	207
Hematologic samples (Stimulated PBMC*)	Stimulated PBMC*	1.2e-07	36	18.8	191	152	1945
Lymphocytes (Stimulated PBMC*)	Stimulated PBMC*	1.2e-07	36	18.8	191	152	1945
Primary blood mononuclear cells (Stimulated PBMC*)	Stimulated PBMC*	1.2e-07	36	18.8	191	152	1945
Cell line (Breast cancer)	Breast cancer	3.4e-07	16	59.2	27	30	152
Activated B like DLBCL (B lymphoma)	B lymphoma	1.1e-06	11	55	20	30	245
Hepatocellular carcinoma (Liver cancer)	Liver cancer	4.2e-06	36	80	45	104	207
Hematologic samples and cell lines (Stimulated PBMC*)	Stimulated PBMC*	1.3e-05	36	18.8	191	182	1945
Monocytes (Stimulated PBMC*)	Stimulated PBMC*	1.3e-05	36	18.8	191	182	1945
B. petrussis A2 stimulated immune cells (Stimulated PBMC)	Stimulated PBMC	2.4e-05	5	26.3	19	5	144
B cells (Leukemia)	Leukemia	4.8e-05	40	62.5	64	62	141
Breast cancer cell line (Breast cancer)	Breast cancer	5.3e-05	10	37.0	27	17	152
Stimulated immune cells (Stimulated PBMC*)	Stimulated PBMC*	6.3e-05	29	15.1	191	143	1945
Invasive liver tumor (Liver cancer)	Liver cancer	7.6e-05	18	40	45	38	207
Female hormonal cancer cell line (Breast cancer)	Breast cancer	0.0001	9	33.3	27	15	152

Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation	P-value	Hits	Hits(%)	Module genes	Genes in annotation	Genes
G-protein coupled receptor protein signaling pathway	7.6e-123	90	100	90	245	4566
conjugation without cellular fusion	1.5e-73	61	67.7	90	152	4566
G-protein coupled receptor activity	1.3e-53	52	57.7	90	170	4566
signal transducer activity	6.0e-45	82	91.1	90	1026	4566
rhodopsin-like receptor activity	7.3e-44	44	48.8	90	147	4566
transmembrane receptor activity	7.2e-39	59	65.5	90	448	4566
receptor activity	3.4e-32	59	65.5	90	582	4566
sensory perception	6.8e-31	62	68.8	90	700	4566
chemosensory perception	1.9e-30	61	67.7	90	682	4566
cell surface receptor linked signal transduction	3.6e-27	40	44.4	90	259	4566
peptide receptor activity	3.4e-26	23	25.5	90	55	4566
peptide receptor activity\, G-protein coupled	1.5e-25	23	25.5	90	58	4566
signal transduction	1.6e-23	59	65.5	90	831	4566
response to abiotic stimulus	2.9e-21	67	74.4	90	1228	4566
cell communication	3.6e-21	62	68.8	90	1030	4566
chemotaxis	6.4e-20	21	23.3	90	73	4566
energy taxis	8.9e-20	21	23.3	90	74	4566
G-protein signaling\, coupled to IP3 second messenger (phospholipase C activating)	1.5e-19	18	20	90	48	4566
taxis	1.6e-19	21	23.3	90	76	4566
integral to plasma membrane	6.6e-19	47	52.2	90	612	4566
cytosolic calcium ion concentration elevation	3.6e-15	12	13.3	90	24	4566
glutamate receptor activity	1.5e-14	14	15.5	90	42	4566
G-protein signaling\, coupled to cyclic nucleotide second messenger	8.9e-14	15	16.6	90	57	4566
G-protein signaling\, coupled to cAMP nucleotide second messenger	1.4e-13	13	14.4	90	39	4566
cAMP-mediated signaling	1.6e-13	12	13.3	90	31	4566
inflammatory response	1.1e-12	18	20	90	108	4566
G-protein signaling\, adenylate cyclase inhibiting pathway	3.0e-12	9	10	90	16	4566
thermoregulation	8.8e-12	17	18.8	90	105	4566
neuropeptide signaling pathway	1.2e-11	11	12.2	90	33	4566
negative regulation of adenylate cyclase activity	1.0e-10	7	7.7	90	10	4566
G-protein chemoattractant receptor activity	2.8e-09	7	7.7	90	14	4566
phospholipase C activation	9.7e-09	6	6.6	90	10	4566
chemokine binding	2.1e-08	6	6.6	90	11	4566
response to starvation	1.3e-07	6	6.6	90	14	4566
response to biotic stimulus	1.4e-07	31	34.4	90	600	4566
feeding behavior	2.1e-07	6	6.6	90	15	4566
nucleotide receptor activity	2.1e-07	6	6.6	90	15	4566
chemokine receptor binding	2.5e-07	8	8.8	90	35	4566
synaptic transmission	2.9e-07	13	14.4	90	116	4566
intracellular signaling cascade	5.5e-07	21	23.3	90	319	4566
coreceptor activity	6.2e-07	5	5.5	90	10	4566
phosphatidylinositol-4\,5-bisphosphate hydrolysis	6.2e-07	5	5.5	90	10	4566
cell motility	1.5e-06	12	13.3	90	113	4566
activation of MAPK	1.8e-06	5	5.5	90	12	4566
MAPKKK cascade (osmolarity sensing)	2.1e-06	6	6.6	90	21	4566
vesicle-mediated transport	4.8e-06	15	16.6	90	196	4566
MAPKKK cascade	6.4e-06	6	6.6	90	25	4566
invasive growth	6.8e-06	5	5.5	90	15	4566
two-component signal transduction system (phosphorelay)	8.3e-06	6	6.6	90	26	4566
cellular morphogenesis	2.4e-05	5	5.5	90	19	4566
heterotrimeric G-protein GTPase\, alpha-subunit	4.1e-05	4	4.4	90	11	4566
regulation of G-protein coupled receptor protein signaling pathway	4.1e-05	4	4.4	90	11	4566
receptor binding	4.3e-05	15	16.6	90	235	4566
response to stress	5.9e-05	31	34.4	90	792	4566
metabotropic glutamate\, GABA-B-like receptor activity	6.1e-05	4	4.4	90	12	4566
immune response	7.4e-05	22	24.4	90	469	4566

Visual display

Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.

You can also view the images within GeneXPress by loading the module gxp file file.

Note: Since there are 619 experiments, this image does not display the individual experiment names, but rather condenses each experiment to a single pixel without displaying its name. You can fully view the image for this module within GeneXPress, by loading any of the four files mentioned in the line above

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