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 >4x |
Module 403 -- DNA damage response |
| General Properties | |
|---|---|
| Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module. | |
| Num gene sets: | 9 |
| Num genes: | 46 (see 487 additional genes for this module) |
| Num experiments: | 535 (229 induced, 306 repressed) |
| Parent module: | 451 |
| Children modules: | 303 318 |
| Gene sets | |
|---|---|
| Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates. | |
| response to DNA damage stimulus | |
| Perou00 45 | |
| Nicotinate_and_nicotinamide_metabolism | |
| Benzoate_degradation | |
| DNA dependent ATPase activity | |
| ATPase activity, coupled | |
| regulation of transcription by pheromones | |
| Boldrick02 34 | |
| viral host cell process manipulation | |
| Enriched clinical annotations | |||||||
|---|---|---|---|---|---|---|---|
| For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched. | |||||||
| Clinical annotation | Category | P-value | Hits | Hits(%) | Module hits in category | Arrays in annotation | Arrays |
| Hematologic cancer and cell line (Stimulated PBMC) | Stimulated PBMC | 8.0e-33 | 29 | 100 | 29 | 30 | 182 |
| Macrophages (Stimulated PBMC) | Stimulated PBMC | 8.0e-33 | 29 | 100 | 29 | 30 | 182 |
| Non-tumor liver tissue (Liver cancer) | Liver cancer | 7.4e-18 | 45 | 86.5 | 52 | 76 | 207 |
| Chronic lymphocytic leukemia (B lymphoma) | B lymphoma | 6.3e-12 | 32 | 49.2 | 65 | 46 | 245 |
| Leukemia (B lymphoma) | B lymphoma | 6.3e-12 | 32 | 49.2 | 65 | 46 | 245 |
| Leukemia or leukemia cell line (B lymphoma) | B lymphoma | 6.3e-12 | 32 | 49.2 | 65 | 46 | 245 |
| Normal lung tissue (Lung cancer) | Lung cancer | 3.7e-11 | 19 | 30.6 | 62 | 22 | 276 |
| Cancer and cell line (Liver cancer) | Liver cancer | 6.5e-11 | 41 | 100 | 41 | 126 | 207 |
| Normal tissue (Lung cancer) | Lung cancer | 1.8e-10 | 19 | 30.6 | 62 | 23 | 276 |
| Liver cancer cell line (Liver cancer) | Liver cancer | 3.5e-08 | 10 | 24.3 | 41 | 10 | 207 |
| Cell line (Liver cancer) | Liver cancer | 3.3e-07 | 10 | 24.3 | 41 | 11 | 207 |
| B. petrussis stimulated immune cells (Stimulated PBMC) | Stimulated PBMC | 5.1e-07 | 20 | 95.2 | 21 | 67 | 144 |
| Cell line (B lymphoma) | B lymphoma | 8.6e-07 | 9 | 33.3 | 27 | 14 | 245 |
| Breast tissue or cancer (NCI60) | NCI60 | 1.0e-06 | 4 | 66.6 | 6 | 4 | 139 |
| Female hormonal tissue or cancer (NCI60) | NCI60 | 1.0e-06 | 4 | 66.6 | 6 | 4 | 139 |
| B cells (B lymphoma*) | B lymphoma* | 1.1e-06 | 63 | 20.5 | 306 | 231 | 1945 |
| Lymphocytes (B lymphoma*) | B lymphoma* | 1.8e-06 | 65 | 21.2 | 306 | 244 | 1945 |
| Hematologic samples and cell lines (Various tumors) | Various tumors | 2.3e-06 | 11 | 84.6 | 13 | 37 | 154 |
| Hematologic samples (Various tumors) | Various tumors | 2.3e-06 | 11 | 84.6 | 13 | 37 | 154 |
| Liver tissue (Liver cancer*) | Liver cancer* | 6.3e-06 | 52 | 16.9 | 306 | 187 | 1945 |
| Gram negative bacteria stimulated immune cells (Stimulated PBMC) | Stimulated PBMC | 1.5e-05 | 20 | 95.2 | 21 | 78 | 144 |
| Small cell lung cancer (Lung cancer) | Lung cancer | 2.1e-05 | 7 | 20.5 | 34 | 10 | 276 |
| Liver tissue, cancer or cell line (Liver cancer*) | Liver cancer* | 3.2e-05 | 52 | 16.9 | 306 | 197 | 1945 |
| B. petrussis 537 stimulated immune cells (Stimulated PBMC) | Stimulated PBMC | 4.2e-05 | 5 | 23.8 | 21 | 5 | 144 |
| B. petrussis A2 stimulated immune cells (Stimulated PBMC) | Stimulated PBMC | 4.2e-05 | 5 | 23.8 | 21 | 5 | 144 |
| B. petrussis Tox 6 stimulated immune cells (Stimulated PBMC) | Stimulated PBMC | 4.2e-05 | 5 | 23.8 | 21 | 5 | 144 |
| Breast cancer (NCI60) | NCI60 | 4.5e-05 | 3 | 50 | 6 | 3 | 139 |
| Hepatitis infected liver (Liver cancer*) | Liver cancer* | 5.7e-05 | 43 | 14.0 | 306 | 156 | 1945 |
| Cell line (Breast cancer) | Breast cancer | 6.3e-05 | 13 | 52 | 25 | 30 | 152 |
| Invasive liver tumor (Liver cancer) | Liver cancer | 7.8e-05 | 17 | 41.4 | 41 | 38 | 207 |
| Cancer (B lymphoma*) | B lymphoma* | 0.0001 | 51 | 16.6 | 306 | 200 | 1945 |
| Hematologic cancer (B lymphoma*) | B lymphoma* | 0.0001 | 51 | 16.6 | 306 | 200 | 1945 |
| Centroblasts (Various tumors) | Various tumors | 0.0001 | 4 | 30.7 | 13 | 5 | 154 |
| GC B like DLBCL (Various tumors) | Various tumors | 0.0001 | 4 | 30.7 | 13 | 5 | 154 |
| T cells (Various tumors) | Various tumors | 0.0001 | 4 | 30.7 | 13 | 5 | 154 |
| Enriched GO annotations | ||||||
|---|---|---|---|---|---|---|
| For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column). | ||||||
| GO annotation | P-value | Hits | Hits(%) | Module genes | Genes in annotation | Genes |
| response to DNA damage stimulus | 3.7e-22 | 27 | 64.2 | 42 | 310 | 4566 |
| regulation of cell cycle | 3.1e-20 | 21 | 50 | 42 | 163 | 4566 |
| DNA metabolism | 4.8e-17 | 19 | 45.2 | 42 | 169 | 4566 |
| viral host cell process manipulation | 1.1e-16 | 16 | 38.0 | 42 | 102 | 4566 |
| ATP binding | 3.4e-12 | 21 | 50 | 42 | 399 | 4566 |
| host-pathogen interaction | 5.2e-12 | 16 | 38.0 | 42 | 198 | 4566 |
| nucleotidyltransferase activity | 1.1e-11 | 21 | 50 | 42 | 425 | 4566 |
| response to stress | 1.3e-11 | 27 | 64.2 | 42 | 792 | 4566 |
| DNA dependent DNA replication | 4.4e-09 | 7 | 16.6 | 42 | 29 | 4566 |
| DNA replication and chromosome cycle | 4.4e-09 | 7 | 16.6 | 42 | 29 | 4566 |
| DNA repair | 6.4e-09 | 10 | 23.8 | 42 | 93 | 4566 |
| nucleus | 1.0e-08 | 26 | 61.9 | 42 | 966 | 4566 |
| cell cycle | 1.9e-08 | 11 | 26.1 | 42 | 135 | 4566 |
| endomembrane system | 4.2e-08 | 26 | 61.9 | 42 | 1029 | 4566 |
| S phase of mitotic cell cycle | 8.4e-08 | 6 | 14.2 | 42 | 26 | 4566 |
| DNA dependent ATPase activity | 1.3e-07 | 6 | 14.2 | 42 | 28 | 4566 |
| cytokinesis | 2.1e-07 | 7 | 16.6 | 42 | 49 | 4566 |
| DNA replication | 3.2e-07 | 7 | 16.6 | 42 | 52 | 4566 |
| mitosis | 4.9e-06 | 6 | 14.2 | 42 | 50 | 4566 |
| protein serine/threonine kinase activity | 6.8e-06 | 8 | 19.0 | 42 | 114 | 4566 |
| transcription\, DNA-dependent | 1.4e-05 | 9 | 21.4 | 42 | 167 | 4566 |
| catalytic activity | 1.9e-05 | 29 | 69.0 | 42 | 1677 | 4566 |
| protein amino acid phosphorylation | 3.0e-05 | 10 | 23.8 | 42 | 230 | 4566 |
| transcription | 3.2e-05 | 9 | 21.4 | 42 | 184 | 4566 |
| regulation of transcription | 5.6e-05 | 6 | 14.2 | 42 | 76 | 4566 |
| primary active transporter activity | 5.8e-05 | 3 | 7.1 | 42 | 9 | 4566 |
| DNA replication initiation | 8.3e-05 | 3 | 7.1 | 42 | 10 | 4566 |
| DNA recombination | 9.3e-05 | 4 | 9.5 | 42 | 27 | 4566 |
| Visual display | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets. | |||||||||
| You can also view the images within GeneXPress by loading the module gxp file file. | |||||||||
| Note: Since there are 535 experiments, this image does not display the individual experiment names, but rather condenses each experiment to a single pixel without displaying its name. You can fully view the image for this module within GeneXPress, by loading any of the four files mentioned in the line above | |||||||||
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