Module 410 -- Cell adhesion

General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets:	3
Num genes:	36 (see 1624 additional genes for this module)
Num experiments:	297 (109 induced, 188 repressed)
Parent module:	None
Children modules:	96

Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
heterophilic cell adhesion
sugar binding
carbohydrate binding

Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation	Category	P-value	Hits	Hits(%)	Module hits in category	Arrays in annotation	Arrays
Liver tissue (Liver cancer*)	Liver cancer*	4.6e-29	54	49.5	109	187	1945
Liver tissue, cancer or cell line (Liver cancer*)	Liver cancer*	9.0e-28	54	49.5	109	197	1945
Hepatitis infected liver (Liver cancer*)	Liver cancer*	1.0e-17	39	35.7	109	156	1945
Prostate (Prostate cancer*)	Prostate cancer*	1.0e-12	35	18.6	188	101	1945
Normal lung tissue (Lung cancer)	Lung cancer	1.1e-08	11	52.3	21	22	276
Normal tissue (Lung cancer)	Lung cancer	2.1e-08	11	52.3	21	23	276
Non-tumor liver tissue (Liver cancer)	Liver cancer	2.9e-08	37	68.5	54	76	207
CNS cancer or cell line (Various tumors)	Various tumors	1.0e-06	11	42.3	26	16	154
CNS tumor (Various tumors)	Various tumors	1.0e-06	11	42.3	26	16	154
Bone marrow (Leukemia)	Leukemia	2.3e-06	12	57.1	21	23	141
B cells (Leukemia)	Leukemia	2.5e-06	19	90.4	21	62	141
Cancer and cell line (Liver cancer)	Liver cancer	2.5e-06	24	100	24	126	207
CNS tissue, cancer or cell line (Various tumors)	Various tumors	4.9e-06	12	46.1	26	21	154
Liver cancer cell line (Liver cancer)	Liver cancer	1.1e-05	7	29.1	24	10	207
Cell line (Liver cancer)	Liver cancer	2.8e-05	7	29.1	24	11	207
Acute lymphocytic leukemia (Leukemia)	Leukemia	3.0e-05	23	100	23	99	149
Breast cancer cell line (Breast cancer)	Breast cancer	3.3e-05	8	50	16	17	152
Lymphocytes (Leukemia)	Leukemia	3.9e-05	21	100	21	91	141
Malignant glioblastoma (Various tumors)	Various tumors	5.2e-05	7	26.9	26	9	154
Cancer and cell line (Lung cancer*)	Lung cancer*	5.4e-05	43	22.8	188	252	1945
Cancer (Lung cancer*)	Lung cancer*	5.4e-05	43	22.8	188	252	1945
Cell line (Breast cancer)	Breast cancer	7.7e-05	10	62.5	16	30	152
Female hormonal cancer cell line (Breast cancer)	Breast cancer	0.0001	7	43.7	16	15	152
Lung cancer (Lung cancer*)	Lung cancer*	0.0001	40	21.2	188	238	1945
Lung cancer or cell line (Lung cancer*)	Lung cancer*	0.0001	40	21.2	188	238	1945

Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).
GO annotation	P-value	Hits	Hits(%)	Module genes	Genes in annotation	Genes
carbohydrate binding	7.9e-78	36	100	36	52	4566
sugar binding	2.4e-74	35	97.2	36	51	4566
heterophilic cell adhesion	2.8e-67	32	88.8	36	44	4566
host-pathogen interaction	9.8e-41	32	88.8	36	198	4566
binding	3.9e-23	36	100	36	1103	4566
cell communication	3.1e-17	32	88.8	36	1030	4566
lectin	1.8e-14	8	22.2	36	14	4566
monosaccharide binding	1.2e-13	7	19.4	36	10	4566
galactose binding	4.2e-12	6	16.6	36	8	4566
humoral defense mechanism (sensu Invertebrata)	2.4e-09	9	25	36	72	4566
humoral immune response	1.9e-07	9	25	36	118	4566
response to pest/pathogen/parasite	2.9e-07	10	27.7	36	163	4566
endocytosis	1.3e-05	5	13.8	36	41	4566
response to biotic stimulus	1.9e-05	15	41.6	36	600	4566

Visual display

Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.

You can also view the images within GeneXPress by loading the module gxp file file.

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