Module 60 -- Heart genes

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General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets: 2
Num genes: 425 (see 3027 additional genes for this module)
Num experiments: 1076 (276 induced, 800 repressed)
Parent module: 88
Children modules: None


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
Heart_2
Heart_1


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation Category P-value Hits Hits(%) Module hits in category Arrays in annotation Arrays
Liver tissue (Liver cancer*) Liver cancer* 4.9e-32 89 32.3 275 187 1945
Liver tissue, cancer or cell line (Liver cancer*) Liver cancer* 8.1e-30 89 32.3 275 197 1945
Cancer and cell line (Lung cancer*) Lung cancer* 1.3e-29 186 23.2 799 252 1945
Cancer (Lung cancer*) Lung cancer* 1.3e-29 186 23.2 799 252 1945
Lung cancer (Lung cancer*) Lung cancer* 5.2e-26 173 21.6 799 238 1945
Lung cancer or cell line (Lung cancer*) Lung cancer* 5.2e-26 173 21.6 799 238 1945
Lung tissue, cancer or cell line (Lung cancer*) Lung cancer* 2.9e-23 189 23.6 799 276 1945
Hepatitis infected liver (Liver cancer*) Liver cancer* 8.7e-23 70 25.4 275 156 1945
Non small cell lung cancer and cell line (Lung cancer*) Lung cancer* 1.4e-21 148 18.5 799 205 1945
Non small cell lung cancer (Lung cancer*) Lung cancer* 1.4e-21 148 18.5 799 205 1945
Prostate (Prostate cancer*) Prostate cancer* 2.7e-17 82 10.2 799 101 1945
Non-tumor liver tissue (Liver cancer) Liver cancer 7.7e-16 60 67.4 89 76 207
Cancer and cell line (Liver cancer) Liver cancer 2.1e-15 67 95.7 70 126 207
Hematologic samples and cell lines (B lymphoma) B lymphoma 1.5e-13 63 84 75 121 245
Acute lymphocytic leukemia (Leukemia) Leukemia 2.5e-13 68 94.4 72 99 149
Lymphocytes (Leukemia) Leukemia 4.6e-12 60 93.7 64 91 141
B cells (Leukemia) Leukemia 6.5e-12 48 75 64 62 141
Epithelial cell line (NCI60) NCI60 1.5e-10 32 41.5 77 32 139
Bone marrow (Leukemia) Leukemia 9.3e-10 23 35.9 64 23 141
Cancer and cell line (Neuro tumors*) Neuro tumors* 2.5e-09 62 7.7 799 86 1945
Cancer (Neuro tumors*) Neuro tumors* 2.5e-09 62 7.7 799 86 1945
CNS cancer or cell line (Neuro tumors*) Neuro tumors* 3.3e-09 59 7.3 799 81 1945
CNS tumor (Neuro tumors*) Neuro tumors* 3.3e-09 59 7.3 799 81 1945
CNS tissue, cancer or cell line (Neuro tumors*) Neuro tumors* 4.7e-09 61 7.6 799 85 1945
Hematologic samples and cell lines (Various tumors) Various tumors 5.1e-09 32 45.7 70 37 154
Hematologic samples (Various tumors) Various tumors 5.1e-09 32 45.7 70 37 154
Diffuse large B cell lymphoma - DLBCL (B lymphoma) B lymphoma 8.7e-09 35 92.1 38 126 245
Hematologic cancer and cell line (Stimulated PBMC) Stimulated PBMC 2.5e-08 13 72.2 18 30 182
Macrophages (Stimulated PBMC) Stimulated PBMC 2.5e-08 13 72.2 18 30 182
Cell line (Breast cancer) Breast cancer 3.8e-08 19 55.8 34 30 152
Diffuse large B cell lymphoma tumor or cell line (B lymphoma) B lymphoma 8.7e-08 35 92.1 38 134 245
Hematologic cancer and cell line (Various tumors) Various tumors 1.2e-07 27 38.5 70 31 154
Hematologic cancer (Various tumors) Various tumors 1.2e-07 27 38.5 70 31 154
Primary blood mononuclear cells (Various tumors) Various tumors 1.2e-07 27 38.5 70 31 154
Activated B like DLBCL (B lymphoma) B lymphoma 1.6e-07 16 42.1 38 30 245
Cancer (Liver cancer) Liver cancer 2.3e-07 56 80 70 115 207
Breast cancer cell line (Breast cancer) Breast cancer 5.4e-07 13 38.2 34 17 152
Lymphocytes (Various tumors) Various tumors 1.7e-06 24 34.2 70 28 154
Monocytes (Various tumors) Various tumors 1.7e-06 24 34.2 70 28 154
Cell line (Liver cancer) Liver cancer 3.7e-06 11 15.7 70 11 207
Female hormonal cancer cell line (Breast cancer) Breast cancer 1.1e-05 11 32.3 34 15 152
Liver cancer cell line (Liver cancer) Liver cancer 1.2e-05 10 14.2 70 10 207
Cell line (B lymphoma) B lymphoma 1.8e-05 12 16 75 14 245
Breast tissue or cancer (NCI60) NCI60 9.1e-05 4 26.6 15 4 139
Female hormonal tissue or cancer (NCI60) NCI60 9.1e-05 4 26.6 15 4 139
B cells (Various tumors) Various tumors 9.8e-05 19 27.1 70 23 154
Breast tissue, cancer or cell line (NCI60) NCI60 0.0001 10 66.6 15 31 139
Cancer and cell line (Gliomas*) Gliomas* 0.0001 32 4.0 799 47 1945
Cancer (Gliomas*) Gliomas* 0.0001 32 4.0 799 47 1945
CNS cancer or cell line (Gliomas*) Gliomas* 0.0001 32 4.0 799 47 1945
CNS tissue, cancer or cell line (Gliomas*) Gliomas* 0.0001 32 4.0 799 47 1945
CNS tumor (Gliomas*) Gliomas* 0.0001 32 4.0 799 47 1945
Cell line (NCI60*) NCI60* 0.0001 76 9.5 799 135 1945
Lymphoma or lymphoma cell line (B lymphoma) B lymphoma 0.0002 35 92.1 38 167 245
T cells (B lymphoma) B lymphoma 0.0002 7 9.3 75 7 245
Lymphoma (B lymphoma) B lymphoma 0.0002 36 48 75 77 245
Adenocarcinoma (Liver cancer) Liver cancer 0.0002 45 64.2 70 97 207
Cancer and cell line (Various tumors) Various tumors 0.0002 58 82.8 70 105 154
Cancer (Various tumors) Various tumors 0.0002 58 82.8 70 105 154
Metastasis (Liver cancer) Liver cancer 0.0002 9 12.8 70 10 207
Hepatocellular carcinoma (Liver cancer) Liver cancer 0.0004 47 67.1 70 104 207
Cancer and cell line (NCI60*) NCI60* 0.0004 76 9.5 799 138 1945
Non-classic malignant glioblastoma (Gliomas) Gliomas 0.0004 13 72.2 18 13 27
Medulloblastoma (Neuro tumors) Neuro tumors 0.0004 50 78.1 64 60 90
Vincristine chemotherapy (Neuro tumors) Neuro tumors 0.0004 50 78.1 64 60 90


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).


Jump to: Home | General properties | Gene sets | Enriched clinical annotations | Enriched Go annotations | Visual display
Visual display
Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.
You can also view the images within GeneXPress by loading the module gxp file file.
Note: Since there are 1076 experiments, this image does not display the individual experiment names, but rather condenses each experiment to a single pixel without displaying its name. You can fully view the image for this module within GeneXPress, by loading any of the four files mentioned in the line above
 
 





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