Module 503

General Properties
Below we list the number of gene sets from which the module was composed was originally composed, and the number of genes and experiments that it contains. Clicking on the number of genes will display a detailed list of all the genes in the module. Clicking on the number of experiments will display a detailed list of all the experiments in the module.
Num gene sets:	8
Num genes:	114 (see 481 additional genes for this module)
Num experiments:	99 (23 induced, 76 repressed)
Parent module:	576
Children modules:	356

Gene sets
Below we list the gene sets from which the module was originally composed. Clicking on a gene set will display all the genes associated with that gene set. Also listed are all the other modules in which the gene set participates.
Perou99 1
Perou99 21
Perou99 25
Perou99 24
Perou99 37
Perou99 36
Perou99 9
Perou99 23

Enriched clinical annotations
For each of the clinical annotations, we tested whether it was enriched in the set of arrays in which the module is significantly induced (or repressed). Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of induced (or repressed) module's arrays in which they appear. We also show the fraction of the module's induced (or repressed) arrays with the given annotation ('Hits (%)' column). For completeness, we also list the total number of relevant induced arrays in the module ('Module hits in category' column), total number of arrays in the compendium in which the corresponding annotation is present ('Arrays in annotation' column), and the total number of relevant arrays in the compendium ('Arrays' column). Note that the 'relevant' arrays may be different for each annotation, since it includes only arrays in which the annotation was relevant (i.e., present or not present) and excludes arrays where the value of the annotation was not known. Rows that correspond to annotations that were enriched in the induced arrays of the module have a red background, while rows corresponding to annotations enriched in the repressed arrays have a green background. For each annotation, we also list the other modules in which it was enriched.
Clinical annotation	Category	P-value	Hits	Hits(%)	Module hits in category	Arrays in annotation	Arrays
Epithelial cell line (Breast cancer)	Breast cancer	1.9e-09	10	83.3	12	18	152
Normal female hormonal tissue and cells (Breast cancer)	Breast cancer	4.2e-09	9	75	12	14	152
Female hormonal tissue, cancer or cell line (Breast cancer*)	Breast cancer*	9.0e-09	12	52.1	23	141	1945
Breast tissue, cancer or cell line (Breast cancer*)	Breast cancer*	9.8e-09	12	52.1	23	142	1945
Human mammary epithelial cells - HMECs (Breast cancer)	Breast cancer	1.2e-08	8	66.6	12	11	152
Cell line (Breast cancer)	Breast cancer	3.3e-08	11	91.6	12	30	152
Human mammary epithelial cells (HMECs) or normal breast tissue (Breast cancer)	Breast cancer	4.8e-08	9	75	12	17	152
Cancer and cell line (Breast cancer*)	Breast cancer*	1.4e-07	11	47.8	23	143	1945
Cancer and cell line (Gliomas*)	Gliomas*	8.7e-07	11	14.4	76	47	1945
Cancer (Gliomas*)	Gliomas*	8.7e-07	11	14.4	76	47	1945
CNS cancer or cell line (Gliomas*)	Gliomas*	8.7e-07	11	14.4	76	47	1945
CNS tissue, cancer or cell line (Gliomas*)	Gliomas*	8.7e-07	11	14.4	76	47	1945
CNS tumor (Gliomas*)	Gliomas*	8.7e-07	11	14.4	76	47	1945
Cancer and cell line (Lung cancer*)	Lung cancer*	0.0001	22	28.9	76	252	1945
Cancer (Lung cancer*)	Lung cancer*	0.0001	22	28.9	76	252	1945

Enriched GO annotations
For each GO annotation, we tested whether it was enriched in the set of genes of the module. Below we list all such annotations that were enriched in this module with an FDR corrected p-value of 0.05 ('P-value' column), along with the number ('Hits' column) of the module's genes in which they appear. We also show the fraction of the module's genes with the given GO annotation that are included in this module ('Hits (%)' column). For completeness, we also list the total number of genes in the module ('Module genes' column), total number of genes in the compendium in which the corresponding annotation is present ('Genes in annotation' column), and the total number of genes in the compendium ('Genes' column).

Visual display

Below is a visual display of the module. Shown are those arrays in which the module's genes significantly change, and the direction of change (induction/repression) in each array is indicated (middle, labeled 'Module changes'; red/green row). The arrays that correspond to the significant clinical attributes are also shown (top; brown rows). The gene sets that compose the module are also shown (left) along with an indication of the membership of the module genes in these gene sets.

You can also view the images within GeneXPress by loading the module gxp file file.

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